Alteration of photosensitizer content and parameters of free radical reactions in a patient's blood under photodynamic therapy of malignant tumors

G. N. Lubchenko; Tatyana V. Chichuk; Eugeny Ph. Stranadko

doi:10.1117/12.375261

30 December 1999 Alteration of photosensitizer content and parameters of free radical reactions in a patient's blood under photodynamic therapy of malignant tumors

G. N. Lubchenko, Tatyana V. Chichuk, Eugeny Ph. Stranadko

Author Affiliations +

Proceedings Volume 4059, Laser Use in Oncology II; (1999) https://doi.org/10.1117/12.375261
Event: Selected Papers on Laser Use in Oncology II, 1999, none, Armenia

Abstract

The purpose of this study was to determine the changes in concentrations of the two Russian photosensitizers in blood plasma of patients under Photodynamic therapy. In this work were used two sensitizers of domestic production: Photohem (hematoporphyrin derivative) and Photosense (sulfonated aluminium phtalocyanine). It was found that one month after injection the concentrations of the photosensitizers in blood plasma remained high enough. Was shown alteration of level of apo-(beta) -lipoproteins oxidation and antioxidant activity of blood plasma under the influence of Photodynamic therapy.

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G. N. Lubchenko, Tatyana V. Chichuk, and Eugeny Ph. Stranadko "Alteration of photosensitizer content and parameters of free radical reactions in a patient's blood under photodynamic therapy of malignant tumors", Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); https://doi.org/10.1117/12.375261

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