Three-tiered fluorescence-based system for monitoring activation-related changes in human platelets

Alexander M. Christov; William J. Kostuk; George Jablonsky; Paulette Desjardins; Ruth Courtis; Bernice Jardine; Anne Bailey; June Odlum-Blair; Janice Motiejunas; Sheila McConnell; Alexandra Lucas

doi:10.1117/12.409327

16 November 2000 Three-tiered fluorescence-based system for monitoring activation-related changes in human platelets

Alexander M. Christov, William J. Kostuk, George Jablonsky, Paulette Desjardins, Ruth Courtis, Bernice Jardine, Anne Bailey, June Odlum-Blair, Janice Motiejunas, Sheila McConnell, Alexandra Lucas

Author Affiliations +

Proceedings Volume 4161, Optical Biopsy and Tissue Optics; (2000) https://doi.org/10.1117/12.409327
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

Citation Download Citation

Alexander M. Christov, William J. Kostuk, George Jablonsky, Paulette Desjardins, Ruth Courtis, Bernice Jardine, Anne Bailey, June Odlum-Blair, Janice Motiejunas, Sheila McConnell, and Alexandra Lucas "Three-tiered fluorescence-based system for monitoring activation-related changes in human platelets", Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); https://doi.org/10.1117/12.409327

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available