Photodynamic therapy using Verteporfin and 630-nm laser light in canine esophagus

Masoud Panjehpour; Robert C. DeNovo D.V.M.; Mark G. Petersen; Bergein F. Overholt M.D.; Barbara Kelly; Robert D. Bower; Valery Rubinchik

doi:10.1117/12.424434

9 April 2001 Photodynamic therapy using Verteporfin and 630-nm laser light in canine esophagus

Masoud Panjehpour, Robert C. DeNovo D.V.M., Mark G. Petersen, Bergein F. Overholt M.D., Barbara Kelly, Robert D. Bower, Valery Rubinchik

Author Affiliations +

Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424434
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Objective: The goal ofthis study was to determine a relationship between light dose and the delay time between administration of Verteporfin and light to ablate canine esophageal mucosa. Materials and Methods: Verteporfin was administered IV (0.75 mg/lg). 630-nm light from KTP/Dye laser was delivered using a 9-cm diffuser inside a specially designed reflective 7-cm windowed balloon. Initially, animals were treated at doses of 160 J/cm, 180 J/cm, 200 J/cm, and 220 J/cm 2-3 hours after Verteporfin injection. Based on the acute response in these animals and the plasma Verteporfin clearance, other treatments were devised and tested at 60 J/cm (at 1 5 minutes), 80 J/cm (22 minutes), 100 J/cm (30 minutes), and 145 J/cm (60 minutes). Results: In initial animals, 200 J/cm at 2 hours induced acceptable mucosal ablation. Using this light dose and the plasma drug clearance, subsequent treatments were tested resulting in similar injuries using 60 3/cm (15 minutes), 80 3/cm (22 minutes), 100 3/cm (30 minutes), and 145 J/cm (60 minutes). Conclusions: A relationship was established relating the light dose and the delay time between administration oflight and Verteporfin for ablation ofnormal canine esophageal mucosa.

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Masoud Panjehpour, Robert C. DeNovo D.V.M., Mark G. Petersen, Bergein F. Overholt M.D., Barbara Kelly, Robert D. Bower, and Valery Rubinchik "Photodynamic therapy using Verteporfin and 630-nm laser light in canine esophagus", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); https://doi.org/10.1117/12.424434

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