Design of a novel system for spectroscopy measurements of the aqueous humor

Joe Miller; Deepak G. Uttamchandani

doi:10.1117/12.427915

4 June 2001 Design of a novel system for spectroscopy measurements of the aqueous humor

Joe Miller, Deepak G. Uttamchandani

Proceedings Volume 4253, Optical Fibers and Sensors for Medical Applications; (2001) https://doi.org/10.1117/12.427915
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The authors report on the design of a system which will enable real time measurements of (therapeutic) drug concentrations in the anterior chamber of the eye. Currently the concentration of therapeutic drugs in the anterior chamber is determined by analyzing samples which have been removed from the aqueous humor of laboratory animal eyes. This sampling via paracentesis can be painful and does not provide a continuous measurement. Our system will be far less invasive, removing the need for sampling via paracentesis, and also providing a continuous measurement, enabling a more complete understanding of the kinetics of ophthalmic drugs. A key component in our novel system is a specially constructed contact lens. We report on the design, optimization and manufacture of such a contact lens system capable of directing UV/VIS light in, across and out of the anterior chamber of the eye, thereby enabling absorption spectroscopy measurements of the aqueous humor to be undertaken. Design of the one piece contact lens/mirror system was achieved using the Zemax optical design software package and the lens was fabricated from synthetic fused silica. Results from modeling of the lens and experimental measurements on light propagation across the anterior chamber of animal eyes assisted by the lens will be reported.

Citation Download Citation

Joe Miller and Deepak G. Uttamchandani "Design of a novel system for spectroscopy measurements of the aqueous humor", Proc. SPIE 4253, Optical Fibers and Sensors for Medical Applications, (4 June 2001); https://doi.org/10.1117/12.427915

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available