Effect of low-power (He-Ne) laser on acute mucosal ulceration induced by indomethacin in rats

Gholam-reza Esmaeeli Djavid; Rebecca Erfani; Nasim Amoohashemi; Mahbobeh Pazoki; Sanaz Aghaee; Hamidreza Pazoki Toroudi

doi:10.1117/12.486610

15 October 2002 Effect of low-power (He-Ne) laser on acute mucosal ulceration induced by indomethacin in rats

Gholam-reza Esmaeeli Djavid, Rebecca Erfani, Nasim Amoohashemi, Mahbobeh Pazoki, Sanaz Aghaee, Hamidreza Pazoki Toroudi

Proceedings Volume 4903, Laser Florence 2001: A Window on the Laser Medicine World; (2002) https://doi.org/10.1117/12.486610
Event: Laser Florence 2001: a Window on the Laser Medicine World, 2001, Florence, Italy

Abstract

Background: Low-level laser has been used for treatment of ulcer, as well as, pain relief and inflammatory processes. In the present work, the effect of low power laser on mucosal gastric ulceration-induced by indomethacin in rats has been investigated. Materials and Methods: 16 male Sprague Dawley rats were divided into control (8 rats) and laser exposed group (8 rats). After using ether for anesthesia, 30 mg/kg indomethacin was injected subcutaneously. Exposed stomachs received 30 J He-Ne laser. Five hours later animals were killed and their stomachs were checked and observed for presence of ulceration. Results and Discussion: Gastric mucosal ulceration index was significantly greater in the laser-exposed group than control group. (P=0.02) This experiment suggests that low power He-Ne laser intensified acute mucosal ulcer formation by indomethacin. Changes in the prostaglandin content ofthe stomach may be responsible for these results.

Citation Download Citation

Gholam-reza Esmaeeli Djavid, Rebecca Erfani, Nasim Amoohashemi, Mahbobeh Pazoki, Sanaz Aghaee, and Hamidreza Pazoki Toroudi "Effect of low-power (He-Ne) laser on acute mucosal ulceration induced by indomethacin in rats", Proc. SPIE 4903, Laser Florence 2001: A Window on the Laser Medicine World, (15 October 2002); https://doi.org/10.1117/12.486610

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