Optical modeling of cylindrical light sources within tissue

Zihong Guo; Steven R. Daly; Jennifer K. Matson

doi:10.1117/12.477708

27 August 2003 Optical modeling of cylindrical light sources within tissue

Zihong Guo, Steven R. Daly, Jennifer K. Matson

Proceedings Volume 4961, Laser-Tissue Interaction XIV; (2003) https://doi.org/10.1117/12.477708
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

The objective of this study was to model the optical profile of a proprietary light source in various simulated biological tissues using Monte Carlo based raytracing software. The proprietary light source, built by Light Sciences Corporation, has an LED array at its distal end and is being evaluated for use as an intratumoral PDT treatment device. The light source was scanned in a goniometer to characterize its optical geometry in air and this data provided the basis for an optical model of the device. The bulk scattering effect of the model in biological tissue was then simulated using the raytracing software. The simulated results were further verified with experimental measurements in phantom medium. The simulated results indicated a non-uniform light distribution along the LED array axis in air. In addition, the light distribution at cross section normal to the LED array axis is "butterfly" in shape with the differences of the peak to average approximately ±42%. However, the optical profile of the light source in a bulk scattering tissue became much more uniform than those in air, with a peak to average spread in cross section of ±15%.

Citation Download Citation

Zihong Guo, Steven R. Daly, and Jennifer K. Matson "Optical modeling of cylindrical light sources within tissue", Proc. SPIE 4961, Laser-Tissue Interaction XIV, (27 August 2003); https://doi.org/10.1117/12.477708

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