Use of acousto-optic tunable filter in fluorescence imaging endoscopy

Mounir Bouhifd; Maurice Whelan; Marc Aprahamian

doi:10.1117/12.500700

14 October 2003 Use of acousto-optic tunable filter in fluorescence imaging endoscopy

Mounir Bouhifd, Maurice Whelan, Marc Aprahamian

Proceedings Volume 5143, Novel Optical Instrumentation for Biomedical Applications; (2003) https://doi.org/10.1117/12.500700
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

A prototype instrument for fluorescence-based medical diagnostics in vivo is described. The system consists of a rigid endoscope comprising a UV laser-source for fluorescence excitation and a white light source for direct imaging. An acousto-optic tuneable filter (AOTF) is employed as a full-field tuneable bandpass filter. This allows fast continuous or random-access tuning with high filtering efficiency. A study of the diagnostic potential of fluorescence imaging for pancreatitis was conducted on a rat model. In particular, the aim was to detect autofluorescence of endogenous protoporphyrin IX (PpIX) that has been shown to accumulate in early-stage diseased tissue undergoing an inflammatory response.

Citation Download Citation

Mounir Bouhifd, Maurice Whelan, and Marc Aprahamian "Use of acousto-optic tunable filter in fluorescence imaging endoscopy", Proc. SPIE 5143, Novel Optical Instrumentation for Biomedical Applications, (14 October 2003); https://doi.org/10.1117/12.500700

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