Sparing of normal urothelium in hexyl-aminolevulinate-mediated photodynamic therapy

Laurent Vaucher; Patrice Jichlinski; Norbert Lange; Celine Ritter-Schenk; Hubert van den Bergh; Pavel Kucera

doi:10.1117/12.590561

25 April 2005 Sparing of normal urothelium in hexyl-aminolevulinate-mediated photodynamic therapy

Laurent Vaucher, Patrice Jichlinski, Norbert Lange, Celine Ritter-Schenk, Hubert van den Bergh, Pavel Kucera

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.590561
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

This work determines on an in vitro porcine urothelium model the threshold values of different parameters such as photosensitizer concentration, irradiation parameters and production of reactive oxygen species in order to control the damage on normal urothelium and spare about 50% of normal mucosa. For a three hours HAL incubation time, these threshold values were with blue light (0.75J/cm at 75 mW/cm2 or 0.15J/cm2 at 30 mW/cm2) and with white light (0.55J/cm2, at 30 mW/cm2). This means that for identical fluence rates, the threshold value for white light irradiation may be 3 times higher than for blue light irradiation.

Citation Download Citation

Laurent Vaucher, Patrice Jichlinski, Norbert Lange, Celine Ritter-Schenk, Hubert van den Bergh, and Pavel Kucera "Sparing of normal urothelium in hexyl-aminolevulinate-mediated photodynamic therapy", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.590561

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KEYWORDS

Photodynamic therapy

Luminescence

Tissue optics

Oxygen

Bladder

Scanning electron microscopy

In vitro testing

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