Influence of the excitation wavelength on the tumor-to-healthy contrast in autofluorescence bronchoscopy: a comprehensive study

Tanja Gabrecht; Pascal Uehlinger; Snezana Andrejevic; Pierre Grosjean; Alexandre Radu; Philippe Monnier; Bernd-Claus Weber; Hubert van den Bergh; Georges Wagnieres

doi:10.1117/12.633009

7 October 2005 Influence of the excitation wavelength on the tumor-to-healthy contrast in autofluorescence bronchoscopy: a comprehensive study

Tanja Gabrecht, Pascal Uehlinger, Snezana Andrejevic, Pierre Grosjean, Alexandre Radu, Philippe Monnier, Bernd-Claus Weber, Hubert van den Bergh, Georges Wagnieres

Author Affiliations +

Proceedings Volume 5862, Diagnostic Optical Spectroscopy in Biomedicine III; 586207 (2005) https://doi.org/10.1117/12.633009
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Autofluorescence (AF) bronchoscopy is a useful tool for early cancer detection. However the mechanisms involved in this diagnosis procedure are poorly understood. We present an in vivo autofluorescence imaging study to access the depth of the principal contrast mechanisms within the bronchial tissue comparing a narrow band and broad band violet fluorescence excitation. Knowledge of this parameter is crucial for the optimization of the spectral and optical design of clinical diagnostic AF imaging devices. We observed no differences in the chromatic contrast using the two excitation modes, indicating that the principal contrast mechanisms have a non-superficial character.

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Tanja Gabrecht, Pascal Uehlinger, Snezana Andrejevic, Pierre Grosjean, Alexandre Radu, Philippe Monnier, Bernd-Claus Weber, Hubert van den Bergh, and Georges Wagnieres "Influence of the excitation wavelength on the tumor-to-healthy contrast in autofluorescence bronchoscopy: a comprehensive study", Proc. SPIE 5862, Diagnostic Optical Spectroscopy in Biomedicine III, 586207 (7 October 2005); https://doi.org/10.1117/12.633009

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