Synthesis and bioconjugation of CdSe/CdS core/shell nanoparticles to poly(ethylene glycol) analogues

Kyoungja Woo; Byeong-Seon Kim

doi:10.1117/12.637955

19 January 2006 Synthesis and bioconjugation of CdSe/CdS core/shell nanoparticles to poly(ethylene glycol) analogues

Kyoungja Woo, Byeong-Seon Kim

Proceedings Volume 6036, BioMEMS and Nanotechnology II; 60361N (2006) https://doi.org/10.1117/12.637955
Event: Microelectronics, MEMS, and Nanotechnology, 2005, Brisbane, Australia

Abstract

CdSe core nanoparticles were synthesized from the stearate complex of Cd and Se powder in octadecene solution containing organic stabilizers. After purification, CdS inorganic shell was made on CdSe core to yield CdSe/CdS core/shell nanostructure using successive ion layer adsorption and reaction method. The outmost half layer of the inorganic CdS shell was designed to be cadmium ion layer. Then, the hydrophobic CdSe/CdS was converted to hydrophilic CdSe/CdS-AET by treating with aminoethanethiol (AET). The cadmium half layer on CdSe/CdS surface was an excellent promoter for the covalent conjugation of CdSe/CdS to thiolate of AET. Finally, CdSe/CdS-AET was bioconjugated to a PEG analogue, poly(ethylene glycol) monomethyl ether mono(succinimidyl succinate) ester. The advantage of using AET compared to mercaptopropionic acid was the stabilization of Cd-thiolate bond during the following bioconjugation process. Investigations of semiconductor nanoparticles with different surface materials are discussed using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis), photoluminescence (PL), and Fourier transformed-infrared (FT-IR) spectroscopy.

Citation Download Citation

Kyoungja Woo and Byeong-Seon Kim "Synthesis and bioconjugation of CdSe/CdS core/shell nanoparticles to poly(ethylene glycol) analogues", Proc. SPIE 6036, BioMEMS and Nanotechnology II, 60361N (19 January 2006); https://doi.org/10.1117/12.637955

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