Biochemical characterization of cell-death via Raman spectroscopy

Nagapratima Kunapareddy; Susan Carpenter; James P Freyer; Judith R Mourant

doi:10.1117/12.647232

27 February 2006 Biochemical characterization of cell-death via Raman spectroscopy

Nagapratima Kunapareddy, Susan Carpenter, James P Freyer, Judith R Mourant

Proceedings Volume 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry; 60930V (2006) https://doi.org/10.1117/12.647232
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Necrosis is the dominant form of cell-death that results from several modalities of cancer treatment. An estimate of post-treatment necrosis serves as an useful indicator of treatment efficacy and tumor response. A non-invasive means of identifying necrosis would serve as a useful clinical tool. In this study, we use Raman spectroscopy for the biochemical characterization of necrosis. Necrosis formation in tissue has been modeled in vitro by the use of multicellular spheroids. The relative amounts of various biochemical components have been estimated and correlated with quantitative estimates of necrosis.

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Nagapratima Kunapareddy, Susan Carpenter, James P Freyer, and Judith R Mourant "Biochemical characterization of cell-death via Raman spectroscopy", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 60930V (27 February 2006); https://doi.org/10.1117/12.647232

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KEYWORDS

Raman spectroscopy

Cell death

Tumors

Proteins

Spectroscopy

Statistical analysis

In vitro testing

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