Creation of 4D imaging data using open source image registration software

Kenneth H. Wong; Luis Ibanez; Teo Popa; Kevin Cleary

doi:10.1117/12.656023

10 March 2006 Creation of 4D imaging data using open source image registration software

Kenneth H. Wong, Luis Ibanez, Teo Popa, Kevin Cleary

Proceedings Volume 6141, Medical Imaging 2006: Visualization, Image-Guided Procedures, and Display; 61410O (2006) https://doi.org/10.1117/12.656023
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

4D images (3 spatial dimensions plus time) using CT or MRI will play a key role in radiation medicine as techniques for respiratory motion compensation become more widely available. Advance knowledge of the motion of a tumor and its surrounding anatomy will allow the creation of highly conformal dose distributions in organs such as the lung, liver, and pancreas. However, many of the current investigations into 4D imaging rely on synchronizing the image acquisition with an external respiratory signal such as skin motion, tidal flow, or lung volume, which typically requires specialized hardware and modifications to the scanner. We propose a novel method for 4D image acquisition that does not require any specific gating equipment and is based solely on open source image registration algorithms. Specifically, we use the Insight Toolkit (ITK) to compute the normalized mutual information (NMI) between images taken at different times and use that value as an index of respiratory phase. This method has the advantages of (1) being able to be implemented without any hardware modification to the scanner, and (2) basing the respiratory phase on changes in internal anatomy rather than external signal. We have demonstrated the capabilities of this method with CT fluoroscopy data acquired from a swine model.

Citation Download Citation

Kenneth H. Wong, Luis Ibanez, Teo Popa, and Kevin Cleary "Creation of 4D imaging data using open source image registration software", Proc. SPIE 6141, Medical Imaging 2006: Visualization, Image-Guided Procedures, and Display, 61410O (10 March 2006); https://doi.org/10.1117/12.656023

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available