Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: case of cervical and oral cancers

Gopal Karemore; . Sujatha; Lavanya Rai; Keerthilatha M. Pai; V. B. Kartha; . Santhosh C.

doi:10.1117/12.809930

23 February 2009 Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: case of cervical and oral cancers

Gopal Karemore, . Sujatha, Lavanya Rai, Keerthilatha M. Pai, V. B. Kartha, . Santhosh C.

Author Affiliations +

Proceedings Volume 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII; 71820J (2009) https://doi.org/10.1117/12.809930
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

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Gopal Karemore, . Sujatha, Lavanya Rai, Keerthilatha M. Pai, V. B. Kartha, and . Santhosh C. "Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: case of cervical and oral cancers", Proc. SPIE 7182, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII, 71820J (23 February 2009); https://doi.org/10.1117/12.809930

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