Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

Jessica Lupinacci; Neb Duric; Peter Littrup; Ding Wang; Cuiping Li; Steven Schmidt; Olsi Rama; Lisa Bey-Knight; Lukasz Myc

doi:10.1117/12.812975

13 March 2009 Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy

Jessica Lupinacci, Neb Duric, Peter Littrup, Ding Wang, Cuiping Li, Steven Schmidt, Olsi Rama, Lisa Bey-Knight, Lukasz Myc

Author Affiliations +

Proceedings Volume 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing; 726517 (2009) https://doi.org/10.1117/12.812975
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

As part of an ongoing assessment of the in-vivo performance of a operator independent breast imaging device, based on acoustic tomography, we report on new results obtained with patients undergoing neoadjuvant chemotherapy. Five patients were examined with the prototype on multiple occasions corresponding in time to their chemotherapy sessions. Images of reflection, sound speed and attenuation, representing the entire volume of the breast, were reconstructed from the exam data and analyzed for time-dependent changes during the treatment period. It was found that changes in acoustic properties of the tumors could be measured directly from the images. The measured properties include reflectivity, sound speed and attenuation, leading to measurable changes in the volume, shape and internal attributes of the tumors. These measurements were used to monitor the response of the tumors to the therapy with the long term goal of correlating results with pathological and clinical outcomes. Comparisons with tumor size changes based on traditional US and MRI indicates potential for accurate, quantifiable tracking of tumor volume. Furthermore, our tentative results also show declines in internal properties of the tumors, possibly relating to a reduction in tissue stiffness and/or density. Future work will include an expansion of the study to a larger cohort of patients for determining the statistical significance of our findings.

Citation Download Citation

Jessica Lupinacci, Neb Duric, Peter Littrup, Ding Wang, Cuiping Li, Steven Schmidt, Olsi Rama, Lisa Bey-Knight, and Lukasz Myc "Monitoring breast masses with ultrasound tomography in patients undergoing neoadjuvant chemotherapy", Proc. SPIE 7265, Medical Imaging 2009: Ultrasonic Imaging and Signal Processing, 726517 (13 March 2009); https://doi.org/10.1117/12.812975

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