Dynamic optical angiography of mouse anatomy using radial projections

Richard B. Lam; Robert A. Kruger; Daniel R. Reinecke; Stephen P. DelRio; Michael M. Thornton; Paul A. Picot; Timothy G. Morgan

doi:10.1117/12.841024

23 February 2010 Dynamic optical angiography of mouse anatomy using radial projections

Richard B. Lam, Robert A. Kruger, Daniel R. Reinecke, Stephen P. DelRio, Michael M. Thornton, Paul A. Picot, Timothy G. Morgan

Author Affiliations +

Proceedings Volume 7564, Photons Plus Ultrasound: Imaging and Sensing 2010; 756405 (2010) https://doi.org/10.1117/12.841024
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We demonstrate the feasibility of optical angiography on live mice using a new photoacoustic computed tomography (PCT) scanner. The scanner uses a sparse array of discrete ultrasound detectors geometrically arranged to capture 128 simultaneous radial "projections" through a 25-mm-diameter volume of interest. Denser sets of interleaved radial projections are acquired by rotating the sparse array continuously about its vertical axis during data acquisition. The device has been designed specifically for imaging laboratory mice, which remain stationary during data collection. Angiographic data are acquired at a rate of 1280 radial projections per second following a bolus injection of 2 mg/mL of indocyanine green (ICG).

Citation Download Citation

Richard B. Lam, Robert A. Kruger, Daniel R. Reinecke, Stephen P. DelRio, Michael M. Thornton, Paul A. Picot, and Timothy G. Morgan "Dynamic optical angiography of mouse anatomy using radial projections", Proc. SPIE 7564, Photons Plus Ultrasound: Imaging and Sensing 2010, 756405 (23 February 2010); https://doi.org/10.1117/12.841024

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