Detection of familial adenomatous polyposis with polarized spectroscopic imaging and oral vascular density

Ali Basiri; Daniel L. Edelstein; Francis M. Giardiello; J. C. Ramella-Roman

doi:10.1117/12.875193

17 February 2011 Detection of familial adenomatous polyposis with polarized spectroscopic imaging and oral vascular density

Ali Basiri, Daniel L. Edelstein, Francis M. Giardiello, J. C. Ramella-Roman

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Proceedings Volume 7897, Optical Interactions with Tissue and Cells XXII; 78970P (2011) https://doi.org/10.1117/12.875193
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer in later years. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. Genetic testing is expensive and in some cases deleterious mutations are not found in all patients with a clinical diagnosis of FAP. As such, the early identification of affected individuals could substantially eliminate associated morbidity and mortality. We investigated a novel spectro-polarimetric imaging system to capture images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Total diffused oral mucosal reflectance (OMR) and oral mucosal vascular density (OMVD) were calculated from spectral data collected from 33 patients with gene positive FAP, 5 patients who tested negative for FAP, and 45 controls. A statistically significant difference in OMVD (p < 0.001) was observed between individuals with FAP and controls. Analysis of OMR showed no significant difference between the two subject groups.

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Ali Basiri, Daniel L. Edelstein, Francis M. Giardiello, and J. C. Ramella-Roman "Detection of familial adenomatous polyposis with polarized spectroscopic imaging and oral vascular density", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78970P (17 February 2011); https://doi.org/10.1117/12.875193

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KEYWORDS

Control systems

Reflectivity

Colorectal cancer

Genetics

Laser induced plasma spectroscopy

Error control coding

Imaging spectroscopy

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