Compact and highly stable quantum dots through optimized aqueous phase transfer

Sudarsan Tamang; Grégory Beaune; Cathy Poillot; Michel De Waard; Isabelle Texier-Nogues; Peter Reiss

doi:10.1117/12.873805

11 February 2011 Compact and highly stable quantum dots through optimized aqueous phase transfer

Sudarsan Tamang, Grégory Beaune, Cathy Poillot, Michel De Waard, Isabelle Texier-Nogues, Peter Reiss

Proceedings Volume 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI; 79091B (2011) https://doi.org/10.1117/12.873805
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A large number of different approaches for the aqueous phase transfer of quantum dots have been proposed. Surface ligand exchange with small hydrophilic thiols, such as L-cysteine, yields the lowest particle hydrodynamic diameter. However, cysteine is prone to dimer formation, which limits colloidal stability. We demonstrate that precise pH control during aqueous phase transfer dramatically increases the colloidal stability of InP/ZnS quantum dots. Various bifunctional thiols have been applied. The formation of disulfides, strongly diminishing the fluorescence QY has been prevented through addition of appropriate reducing agents. Bright InP/ZnS quantum dots with a hydrodynamic diameter <10 nm and long-term stability have been obtained. Finally we present in vitro studies of the quantum dots functionalized with the cell-penetrating peptide maurocalcine.

Citation Download Citation

Sudarsan Tamang, Grégory Beaune, Cathy Poillot, Michel De Waard, Isabelle Texier-Nogues, and Peter Reiss "Compact and highly stable quantum dots through optimized aqueous phase transfer", Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79091B (11 February 2011); https://doi.org/10.1117/12.873805

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