Fractal properties of biospeckles formed at the coherent illumination of histological preparation of cancer tissues

Alexander S. Ulyanov; Alexander V. Zotov

doi:10.1117/12.891723

12 April 2011 Fractal properties of biospeckles formed at the coherent illumination of histological preparation of cancer tissues

Alexander S. Ulyanov, Alexander V. Zotov

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Proceedings Volume 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII; 79990L (2011) https://doi.org/10.1117/12.891723
Event: Saratov Fall Meeting 2010, 2010, Saratov, Russian Federation

Abstract

Traditional biological and chemical methods for pathogen identification require complicated sample preparation for reliable results. The process of identification of malignant and non-malignant growths is not easier. Two new techniques of analysis of speckle-patterns, formed by histological sections with malignant and non-malignant growths illuminated by laser light, were proposed in this article. One of these techniques is based on calculation of invariant Zernike moments of speckle-field intensity spatial distribution. The second technique is based on calculation of fractal dimension of intensity spatial distribution in speckle structure. It was shown that both of these methods give the same results, which drastically depends on tissues features. Possibility of using Zernike moments and fractal dimensions, formed by laser light dispersed on histological sections, in express-diagnostics of tissues with pathological changes carrying out in vitro was investigated. Dependence of fractal dimension n conditions of irradiation of object with laser light discussed.

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Alexander S. Ulyanov and Alexander V. Zotov "Fractal properties of biospeckles formed at the coherent illumination of histological preparation of cancer tissues", Proc. SPIE 7999, Saratov Fall Meeting 2010: Optical Technologies in Biophysics and Medicine XII, 79990L (12 April 2011); https://doi.org/10.1117/12.891723

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KEYWORDS

Fractal analysis

Tissues

Gaussian beams

Speckle pattern

Biological research

Cancer

Collimation

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