Realistic phantoms for diffuse optical imaging using totally absorbing objects

Antonio Pifferi; Fabrizio Martelli; Davide Contini; Lorenzo Spinelli; Alessandro Torricelli; Heidrun Wabnitz; Rainer Macdonald; Angelo Sassaroli; Giovanni Zaccanti

doi:10.1117/12.2003665

28 February 2013 Realistic phantoms for diffuse optical imaging using totally absorbing objects

Antonio Pifferi, Fabrizio Martelli, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Giovanni Zaccanti

Author Affiliations +

Proceedings Volume 8583, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V; 85830C (2013) https://doi.org/10.1117/12.2003665
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We propose and validate the design of inhomogeneous phantoms for diffuse optical imaging purposes using totally absorbing objects embedded in a diffusive medium. From Monte Carlo simulations, we show that a given or desired perturbation strength caused by an realistic absorbing inhomogeneity of a certain absorption and volume can be approximately mimicked by a small totally absorbing object of a so-called Equivalent Black Volume (Equivalence Relation). This concept can be useful to design realistic inhomogeneous phantoms using a set of black objects with different volumes. Further, it permits to grade physiological or pathological changes on a reproducible scale of equivalent black volumes, thus facilitating the performance assessment of clinical instruments. We have also provided a plot to derive the Equivalent Black Volume yielding the same effect of a realistic absorption object.

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Antonio Pifferi, Fabrizio Martelli, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, and Giovanni Zaccanti "Realistic phantoms for diffuse optical imaging using totally absorbing objects", Proc. SPIE 8583, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue V, 85830C (28 February 2013); https://doi.org/10.1117/12.2003665

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KEYWORDS

Absorption

Monte Carlo methods

Diffuse optical imaging

Optical spheres

Scattering

Optical properties

Sensors

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