Zepto-mole detection in microfluidics by novel nonlinear multi-photon laser wave-mixing spectroscopy for biomedical and environmental applications

Marcel Hetu; Manna Iwabuchi; Eric Maxwell; Haoli Wu; Sashary Ramos; William G. Tong

doi:10.1117/12.2062373

12 September 2014 Zepto-mole detection in microfluidics by novel nonlinear multi-photon laser wave-mixing spectroscopy for biomedical and environmental applications

Marcel Hetu, Manna Iwabuchi, Eric Maxwell, Haoli Wu, Sashary Ramos, William G. Tong

Author Affiliations +

Proceedings Volume 9193, Novel Optical Systems Design and Optimization XVII; 91930T (2014) https://doi.org/10.1117/12.2062373
Event: SPIE Optical Engineering + Applications, 2014, San Diego, California, United States

Abstract

Laser wave-mixing detectors for microfluidics are presented as compact systems for parts-per-quadrillion-level detection of biomedical and environmental samples. Wave mixing offers unique advantages including absorption-based detection of micrometer-thin samples, generation of coherent laser-like signal beams, and sensitive detection of both fluorescing and non-fluorescing samples. Biomarkers could be detected in their native forms without labels, or if labels are desired, one could use both fluorophores and chromophores as labels. By coupling low-power (mW) solid-state lasers and microfluidics and microarrays, one can design compact optical systems that can be battery powered and used in the field for real-time fingerprinting of chemicals.

Citation Download Citation

Marcel Hetu, Manna Iwabuchi, Eric Maxwell, Haoli Wu, Sashary Ramos, and William G. Tong "Zepto-mole detection in microfluidics by novel nonlinear multi-photon laser wave-mixing spectroscopy for biomedical and environmental applications", Proc. SPIE 9193, Novel Optical Systems Design and Optimization XVII, 91930T (12 September 2014); https://doi.org/10.1117/12.2062373

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