Transcranial low-level laser therapy increases memory, learning, neuroprogenitor cells, BDNF and synaptogenesis in mice with traumatic brain injury

Weijun Xuan; Liyi Huang; Fatma Vatansever; Tanupriya Agrawal; Michael R. Hamblin

doi:10.1117/12.2081022

5 March 2015 Transcranial low-level laser therapy increases memory, learning, neuroprogenitor cells, BDNF and synaptogenesis in mice with traumatic brain injury

Weijun Xuan, Liyi Huang, Fatma Vatansever, Tanupriya Agrawal, Michael R. Hamblin

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Proceedings Volume 9309, Mechanisms for Low-Light Therapy X; 93090C (2015) https://doi.org/10.1117/12.2081022
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Increasing concern is evident over the epidemic of traumatic brain injury in both civilian and military medicine, and the lack of approved treatments. Transcranial low level laser therapy tLLLT) is a new approach in which near infrared laser is delivered to the head, penetrates the scalp and skull to reach the brain. We asked whether tLLLT at 810-nm could improve memory and learning in mice with controlled cortical impact traumatic brain injury. We investigated the mechanism of action by immunofluorescence studies in sections from brains of mice sacrificed at different times. Mice with TBI treated with 1 or 3 daily laser applications performed better on Morris Water Maze test at 28 days. Laser treated mice had increased BrdU incorporation into NeuN positive cells in the dentate gyrus and subventricular zone indicating formation of neuroprogenitor cells at 7 days and less at 28 days. Markers of neuron migration (DCX and Tuj1) were also increased, as was the neurotrophin, brain derived neurotrophic factor (BDNF) at 7 days. Markers of synaptogenesis (formation of new connections between existing neurons) were increased in the perilesional cortex at 28 days. tLLLT is proposed to be able to induce the brain to repair itself after injury. However its ability to induce neurogenesis and synaptogenesis suggests that tLLLT may have much wider applications to neurodegenerative and psychiatric disorders.

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Weijun Xuan, Liyi Huang, Fatma Vatansever, Tanupriya Agrawal, and Michael R. Hamblin "Transcranial low-level laser therapy increases memory, learning, neuroprogenitor cells, BDNF and synaptogenesis in mice with traumatic brain injury", Proc. SPIE 9309, Mechanisms for Low-Light Therapy X, 93090C (5 March 2015); https://doi.org/10.1117/12.2081022

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KEYWORDS

Traumatic brain injury

Brain

Laser therapeutics

Neurogenesis

Synaptogenesis

Injuries

Neurons

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