Coupling of physical characteristics of non-ionizing irradiation to specific mechanisms of cell death: are we there yet?

Sharon Thomsen

doi:10.1117/12.2080881

11 March 2015 Coupling of physical characteristics of non-ionizing irradiation to specific mechanisms of cell death: are we there yet?

Sharon Thomsen

Author Affiliations +

Proceedings Volume 9326, Energy-based Treatment of Tissue and Assessment VIII; 932603 (2015) https://doi.org/10.1117/12.2080881
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

The recent discovery of the various specific" triggers" and mechanisms of cell life and death responses suggests that certain non-ionizing irradiation spectra and other physical signals could be coupled with specific cellular "triggers" to improve diagnostic or treatment effects. Genetic, chemical and/or physical modifications of specific extrinsic cellular "triggers" have centered on chemical binding of specific molecules to specific receptors, i.e. chemical " triggers" thus allowing development of specific drugs to counteract the initiating function of the “triggers” in single cells. Investigations of non-ionizing irradiation effects on cells and tissues indicate that their “triggers” involve intimate interactions of linked components of the extracellular matrix and the cytoskeleton in tissues. Therefore, the search for single “triggers” that may work well for chemical “triggers” in single cells in culture may not be effective for discovery of the mechanisms that initiate sensing of the stimulations of non-ionizing irradiation and mechanical force.

Citation Download Citation

Sharon Thomsen "Coupling of physical characteristics of non-ionizing irradiation to specific mechanisms of cell death: are we there yet?", Proc. SPIE 9326, Energy-based Treatment of Tissue and Assessment VIII, 932603 (11 March 2015); https://doi.org/10.1117/12.2080881

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Proteins

Tissues

Cell death

Cytoskeletons

Receptors

Ion channels

Macromolecules

Show All Keywords

Keywords/Phrases

Search In:

Publication Years