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7 March 2022 Spectral characteristics of retinal melanin in the near infrared: a comparison of mouse and human OCT data
Conrad W. Merkle, Sylvia Desissaire, Michael Pircher, Christoph Hitzenberger, Bernhard Baumann
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Proceedings Volume PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI; PC1194813 (2022) https://doi.org/10.1117/12.2610766
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Degradation or migration of melanin within the retina is an important biomarker for ophthalmic diagnostics. Here we investigate spectral analysis of optical coherence tomography (OCT) data for measuring melanin in the retina. We demonstrated that a near infrared clinical OCT system was able to produce spectral signals for melanin in the retinal pigment epithelium and choroid. Our results showed lower melanin concentrations in the choroid for a human compared to a mouse. Because spectral analysis can be performed on standard OCT data, these methods may be readily integrated into clinical systems around the world without the need for new hardware.
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Conrad W. Merkle, Sylvia Desissaire, Michael Pircher, Christoph Hitzenberger, and Bernhard Baumann "Spectral characteristics of retinal melanin in the near infrared: a comparison of mouse and human OCT data", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194813 (7 March 2022); https://doi.org/10.1117/12.2610766
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KEYWORDS
Optical coherence tomography
Near infrared
Imaging systems
Retina
Spectroscopy
Eye
Imaging spectroscopy
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