A portable light detector for measuring in-vivo bioluminescent activity

Sergey V. Polyakov; George Eppeldauer; Aleksey Yevtodiyenko; Arkadiy Bazhin; Pavlo Khodakivskyi; Aurelien Godinat; Ghyslain Budin; Tamara Maric; Giorgio Pietramaggiori; Sandra S Scherer; Marina Kunchulia; Kevin Francis; Jeffrey N. Bryan; Elena Goun

doi:10.1117/12.2609941

7 March 2022 A portable light detector for measuring in-vivo bioluminescent activity

Sergey V. Polyakov, George Eppeldauer, Aleksey Yevtodiyenko, Arkadiy Bazhin, Pavlo Khodakivskyi, Aurelien Godinat, Ghyslain Budin, Tamara Maric, Giorgio Pietramaggiori, Sandra S Scherer, Marina Kunchulia, Kevin Francis, Jeffrey N. Bryan, Elena Goun

Author Affiliations +

Proceedings Volume PC11950, Optics and Biophotonics in Low-Resource Settings VIII; PC1195007 (2022) https://doi.org/10.1117/12.2609941
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Here we introduce a portable low-noise detector for characterization of faint bioluminescent light produced in in vitro, in-vivo, and ex-vivo settings including non-transgenic animals. To demonstrate sensor’s capabilities, we present functionalized bioluminescent measurements with in-vivo transgenic and non-transgenic mice, dogs, and ex-vivo human tissue. Due to its versatility, low cost and straightforward calibration, this detector is particularly useful for animal models that are not compatible with commercial bioluminescent imagers and/or for laboratories with budgetary constraints.

Conference Presentation

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Sergey V. Polyakov, George Eppeldauer, Aleksey Yevtodiyenko, Arkadiy Bazhin, Pavlo Khodakivskyi, Aurelien Godinat, Ghyslain Budin, Tamara Maric, Giorgio Pietramaggiori, Sandra S Scherer, Marina Kunchulia, Kevin Francis, Jeffrey N. Bryan, and Elena Goun "A portable light detector for measuring in-vivo bioluminescent activity", Proc. SPIE PC11950, Optics and Biophotonics in Low-Resource Settings VIII, PC1195007 (7 March 2022); https://doi.org/10.1117/12.2609941

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