Alterations in collagen mechanical characteristics related to aging observed by AFM and acoutstic microscopy

Anna R. Maeva; Adam Strange; Ina Seviaryna; Colin Hopper; Conal Perrett; Hugh Trahair; Oliver Devine; Arne Akbar

doi:10.1117/12.2618163

28 October 2022 Alterations in collagen mechanical characteristics related to aging observed by AFM and acoutstic microscopy

Anna R. Maeva, Adam Strange, Ina Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, Arne Akbar

Author Affiliations +

Proceedings Volume PC11952, Multimodal Biomedical Imaging XVII; PC119520K (2022) https://doi.org/10.1117/12.2618163
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

Ageing affects both the structure and the function of the skin. This results in degradation of physiological functions and biophysical properties of organs and tissues putting an alarming economic and social burden on governments and healthcare services. Any significant alteration of skin’s mechanical properties that could affect its structural integrity and barrier function has the potential to cause health effects. With age, the collagen and elastin fibre networks in the dermis become compacted leading to reduction in dermis thickness. Skin photoaging leads to solar elastosis or disintegration of elastic fibers and accumulation of amorphous, thick ended, fragmented elastic fibers. The skin aging process is not yet fully understood.

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Anna R. Maeva, Adam Strange, Ina Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, and Arne Akbar "Alterations in collagen mechanical characteristics related to aging observed by AFM and acoutstic microscopy", Proc. SPIE PC11952, Multimodal Biomedical Imaging XVII, PC119520K (28 October 2022); https://doi.org/10.1117/12.2618163

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