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17 March 2023 Multiplexing molecular spectroscopy via metasurface using plasmonic resonance energy transfer
Hongyoon Kim, Inki Kim, Seungyeon Han, Joohoon Kim, Yangkyu Kim, Inhee Choi, Junsuk Rho, Luke P. Lee
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Proceedings Volume PC12432, High Contrast Metastructures XII; PC124320L (2023) https://doi.org/10.1117/12.2647810
Event: SPIE OPTO, 2023, San Francisco, California, United States
Abstract
Plasmonic resonance energy transfer (PRET) based imaging has been proposed as an effective label-free real-time biomolecular absorption spectroscopic method that enables the detection of biomolecules and dynamic cell activities. Here, we present a metasurface-based PRET-imaging platform that effectively engineers the darkfield scattering spectrum using the gap plasmon and grating effect. As a demonstration, three different biomolecules (Cyt c, Chl a, Chl b) are simultaneously detected using our metasurface-based PRET-imaging platform. Our proposed metasurface-based PRET-imaging platform enables continuous monitoring in the spatial region and multiplexed PRET sensing of multiple biomolecules with different absorption spectrums in the visible.
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Hongyoon Kim, Inki Kim, Seungyeon Han, Joohoon Kim, Yangkyu Kim, Inhee Choi, Junsuk Rho, and Luke P. Lee "Multiplexing molecular spectroscopy via metasurface using plasmonic resonance energy transfer", Proc. SPIE PC12432, High Contrast Metastructures XII, PC124320L (17 March 2023); https://doi.org/10.1117/12.2647810
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KEYWORDS
Plasmonics
Multiplexing
Nanoparticles
Resonance energy transfer
Absorption
Molecular spectroscopy
Scattering
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