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13 March 2024 Effect of photoxidation on bacterial persistence
Bruna Corrêa, Vanderlei Bagnato, Kate C. Blanco
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Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220N (2024) https://doi.org/10.1117/12.3004206
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Antimicrobial resistance is a global health problem that stems from the indiscriminate use of antibiotics, resulting in the emergence and spread of resistant pathogens. Bacterial persistence is a phenomenon where cells survive prolonged exposure to a bactericidal antibiotic despite being genetically susceptible Photodynamic inactivation (PDI) combines the use of photosensitizers and specific light to generate reactive oxygen species that can inactivate bacteria. Studies have shown that the combination of PDI and antibiotics has synergistic effects in treating infections. The use of PDI combined with antibiotics is a promising approach for the treatment of persistent infections. This work consists of applying doses of bactericidal antibiotics such as amoxicillin in strains of Staphylococcus aureus to evaluate their time-dependent death, isolate and culture persistent cells for application of subdoses of PDI observing their effects on bacteria with the persistence phenotype.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Bruna Corrêa, Vanderlei Bagnato, and Kate C. Blanco "Effect of photoxidation on bacterial persistence", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220N (13 March 2024); https://doi.org/10.1117/12.3004206
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KEYWORDS
Bacteria
Cell phenotyping
Oxygen
Pathogens
Resistance
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