Line-scanning Raman spectroscopy imaging system for cancer margin detection with spatial-offset depth-resolved imaging capabilities

Hugo Tavera; Sandryne David; François Daoust; Guillaume Sheehy; Trang Tran; Sarkis Meterissian; Frédéric Leblond

doi:10.1117/12.3003091

13 March 2024 Line-scanning Raman spectroscopy imaging system for cancer margin detection with spatial-offset depth-resolved imaging capabilities

Hugo Tavera, Sandryne David, François Daoust, Guillaume Sheehy, Trang Tran, Sarkis Meterissian, Frédéric Leblond

Author Affiliations +

Proceedings Volume PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC1283609 (2024) https://doi.org/10.1117/12.3003091
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Using dual-modality imaging, we can detect with this system the molecular composition of tissues on a 1 cm² area. Visible light imaging is done in real-time through an RGB camera, while the Raman modality uses a line-scanning system for surface imaging and has a spatial resolution of 250 μm² as well as a spectral resolution of 8 cm-1 for measurements just under 10 seconds. This system is used for ex-vivo measurements, where in a recent study, this system differentiated invasive breast cancer from normal breast tissues based on an SVM classification model.

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Hugo Tavera, Sandryne David, François Daoust, Guillaume Sheehy, Trang Tran, Sarkis Meterissian, and Frédéric Leblond "Line-scanning Raman spectroscopy imaging system for cancer margin detection with spatial-offset depth-resolved imaging capabilities", Proc. SPIE PC12836, Optical Biopsy XXII: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC1283609 (13 March 2024); https://doi.org/10.1117/12.3003091

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