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13 March 2024 Envelope spike function and antigenicity by single molecule imaging
Krishanu Ray
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Proceedings Volume PC12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI; PC1285808 (2024) https://doi.org/10.1117/12.3009334
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Through applications of fluorescence correlation spectroscopy, our research has provided a unique view of HIV virion-antibody interactions. We developed a novel FRET-FCS based assay to identify how neutralizing and non-neutralizing epitopes are expressed on single virions. Most of our methods can be expanded for application to studies of in vitro primary infection systems. Recently, we developed a quantitative, intrinsic, label-free, and minimally invasive method based on two-photon fluorescence lifetime (FLT) imaging microscopy (2p-FLIM) for imaging NADH metabolism of virally infected cells and tissue sections.
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Krishanu Ray "Envelope spike function and antigenicity by single molecule imaging", Proc. SPIE PC12858, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI, PC1285808 (13 March 2024); https://doi.org/10.1117/12.3009334
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KEYWORDS
Molecules
Fluorescence correlation spectroscopy
Fluorescence
Fluorescence imaging
Molecular interactions
Microscopy
Mode conditioning cables
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