CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 14 > Issue 2 > Article
Open Access
1 March 2009 Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study
Mikhail Yu. Kirillin, Marina V. Shirmanova, Marina A. Sirotkina, Marina Bugrova, Boris Nokolaevich Khlebtsov, Elena V. Zagainova
Author Affiliations +
Journal of Biomedical Optics, Vol. 14, Issue 2, 021017 (March 2009). https://doi.org/10.1117/1.3122373
Abstract
The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In vivo measurements are performed on pig skin, where nanoparticle suspension drops have been applied. The identification of skin layers is performed by comparison with corresponding histology images. Experimental results exhibit an increase in contrast of the obtained OCT images after a single nanoparticles application. Multiple applications do not lead to increase in the obtained contrast. To interpret the obtained experimental OCT images of skin and understand the mechanisms of contrasting, a set of Monte Carlo calculations is performed. The results of the simulations exhibit good qualitative agreement with the experimental images, and prove that the contrasting originates from the nanoparticles added, while the contrast of inclusion originates from the absence of nanoparticles within it and their presence in the surrounding area.
©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Mikhail Yu. Kirillin, Marina V. Shirmanova, Marina A. Sirotkina, Marina Bugrova, Boris Nokolaevich Khlebtsov, and Elena V. Zagainova "Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study," Journal of Biomedical Optics 14(2), 021017 (1 March 2009). https://doi.org/10.1117/1.3122373
Published: 1 March 2009
JOURNAL ARTICLE
 11 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 78 scholarly publications and 1 patent.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Nanoparticles
Skin
Gold
Optical coherence tomography
Monte Carlo methods
Titanium dioxide
Particles
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top