Photodynamic therapy: superficial and interstitial illumination

Katarina Svanberg M.D.; Niels Bendsoe M.D.; Johan Axelsson; Stefan Andersson-Engels; Sune Svanberg

doi:10.1117/1.3466579

1 July 2010 Photodynamic therapy: superficial and interstitial illumination

Katarina Svanberg M.D., Niels Bendsoe M.D., Johan Axelsson, Stefan Andersson-Engels, Sune Svanberg

Author Affiliations +

Journal of Biomedical Optics, Vol. 15, Issue 4, 041502 (July 2010). https://doi.org/10.1117/1.3466579

Abstract

Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial procedure to deliver the required therapeutic dose based on the assessment of light fluence rate and sensitizer concentration and oxygen level throughout the tumor is presented.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Katarina Svanberg M.D., Niels Bendsoe M.D., Johan Axelsson, Stefan Andersson-Engels, and Sune Svanberg "Photodynamic therapy: superficial and interstitial illumination," Journal of Biomedical Optics 15(4), 041502 (1 July 2010). https://doi.org/10.1117/1.3466579

Published: 1 July 2010

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
10 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY