Light path-length distributions within the retina

Paul I. Rodmell; John A. Crowe; Alistair Gorman; Andrew R. Harvey; Gonzalo Muyo; David J. Mordant; Andrew I. McNaught M.D.; Stephen P. Morgan

doi:10.1117/1.JBO.19.3.036008

10 March 2014 Light path-length distributions within the retina

Paul I. Rodmell, John A. Crowe, Alistair Gorman, Andrew R. Harvey, Gonzalo Muyo, David J. Mordant, Andrew I. McNaught M.D., Stephen P. Morgan

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Journal of Biomedical Optics, Vol. 19, Issue 3, 036008 (March 2014). https://doi.org/10.1117/1.JBO.19.3.036008

Abstract

A Monte Carlo simulation of light propagation through the retina has been developed to understand the path-length distributions within the retinal vessel. For full-field illumination, the path-length distribution within the vessel comprises directly backscattered light and light that has passed once or twice through the vessel. The origins of these light path-length distributions can be better understood by investigating different combinations of single-point illumination and detection positions. Perhaps the most significant observation is that illumination at the edges of the vessel, rather than over the whole field of view, and detection directly above the vessel capture only the light that has taken a single pass through the vessel. This path-length distribution is tightly constrained around the diameter of the vessel and can potentially provide enhancements for oxygen saturation imaging. The method could be practically implemented using an offset-pinhole confocal imaging system or structured light illumination.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Paul I. Rodmell, John A. Crowe, Alistair Gorman, Andrew R. Harvey, Gonzalo Muyo, David J. Mordant, Andrew I. McNaught M.D., and Stephen P. Morgan "Light path-length distributions within the retina," Journal of Biomedical Optics 19(3), 036008 (10 March 2014). https://doi.org/10.1117/1.JBO.19.3.036008

Published: 10 March 2014

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