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18 February 2015 Native fluorescence spectroscopy of blood plasma of rats with experimental diabetes: identifying fingerprints of glucose-related metabolic pathways
Evgeny A. Shirshin, Olga P. Cherkasova, Tatiana Tikhonova, Elena Berlovskaya, Alexander V. Priezzhev, Victor Fadeev
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Journal of Biomedical Optics, Vol. 20, Issue 5, 051033 (February 2015). https://doi.org/10.1117/1.JBO.20.5.051033
Abstract
We present the results of a native fluorescence spectroscopy study of blood plasma of rats with experimental diabetes. It was shown that the fluorescence emission band shape at 320 nm excitation is the most indicative of hyperglycemia in the blood plasma samples. We provide the interpretation of this fact based on the changes in reduced nicotinamide adenine dinucleotide phosphate concentration due to glucose-related metabolic pathways and protein fluorescent cross-linking formation following nonenzymatic glycation.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Evgeny A. Shirshin, Olga P. Cherkasova, Tatiana Tikhonova, Elena Berlovskaya, Alexander V. Priezzhev, and Victor Fadeev "Native fluorescence spectroscopy of blood plasma of rats with experimental diabetes: identifying fingerprints of glucose-related metabolic pathways," Journal of Biomedical Optics 20(5), 051033 (18 February 2015). https://doi.org/10.1117/1.JBO.20.5.051033
Published: 18 February 2015
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KEYWORDS
Luminescence
Blood
Plasma
Proteins
Glucose
Fluorescence spectroscopy
Plasma spectroscopy
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