Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

Shinsuke Nirengi; Naohiko Inoue; Toshiyuki Homma; Hitoshi Sato; Mami Matsushita; Toshimitsu Kameya; Takeshi Yoneshiro; Hiroki Sugie M.D.; Kokoro Tsuzaki; Masayuki Saito; Naoki Sakane; Yuko Kurosawa; Takafumi Hamaoka

doi:10.1117/1.JBO.21.9.091305

2 May 2016 Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

Shinsuke Nirengi, Naohiko Inoue, Toshiyuki Homma, Hitoshi Sato, Mami Matsushita, Toshimitsu Kameya, Takeshi Yoneshiro, Hiroki Sugie M.D., Kokoro Tsuzaki, Masayuki Saito, Naoki Sakane, Yuko Kurosawa, Takafumi Hamaoka

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Journal of Biomedical Optics, Vol. 21, Issue 9, 091305 (May 2016). https://doi.org/10.1117/1.JBO.21.9.091305

Abstract

¹⁸F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), a recognized therapeutic target of obesity. However, a longitudinal BAT study using FDG-PET/CT is lacking owing to limitations of the method. Near-infrared time-resolved spectroscopy (NIR_TRS) is a technique for evaluating human BAT density noninvasively. This study aimed to test whether NIR_TRS could detect changes in BAT density during or after long-term intervention. First, using FDG-PET/CT, we confirmed a significant increase (+48.8%, P<0.05) in BAT activity in the supraclavicular region after 6-week treatment with thermogenic capsaicin analogs, capsinoids. Next, 20 volunteers were administered either capsinoids or placebo daily for 8 weeks in a double-blind design, and BAT density was measured using NIR_TRS every 2 weeks during the 8-week treatment period and an 8-week period after stopping treatment. Consistent with FDG-PET/CT results, NIR_TRS successfully detected an increase in BAT density during the 8-week treatment (+46.4%, P<0.05), and a decrease in the 8-week follow-up period (−12.5%, P=0.07), only in the capsinoid-treated, but not the placebo, group. Thus, NIR_TRS can be applied for quantitative assessment of BAT in longitudinal intervention studies in humans.

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Shinsuke Nirengi, Naohiko Inoue, Toshiyuki Homma, Hitoshi Sato, Mami Matsushita, Toshimitsu Kameya, Takeshi Yoneshiro, Hiroki Sugie M.D., Kokoro Tsuzaki, Masayuki Saito, Naoki Sakane, Yuko Kurosawa, and Takafumi Hamaoka "Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy," Journal of Biomedical Optics 21(9), 091305 (2 May 2016). https://doi.org/10.1117/1.JBO.21.9.091305

Published: 2 May 2016

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