Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics

Yury V. Kistenev; Alexey V. Borisov; Maria A. Titarenko; Olga D. Baydik; Alexander V. Shapovalov

doi:10.1117/1.JBO.23.4.045001

13 April 2018 Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics

Yury V. Kistenev, Alexey V. Borisov, Maria A. Titarenko, Olga D. Baydik, Alexander V. Shapovalov

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Journal of Biomedical Optics, Vol. 23, Issue 4, 045001 (April 2018). https://doi.org/10.1117/1.JBO.23.4.045001

Abstract

The ability to diagnose oral lichen planus (OLP) based on saliva analysis using THz time-domain spectroscopy and chemometrics is discussed. The study involved 30 patients (2 male and 28 female) with OLP. This group consisted of two subgroups with the erosive form of OLP (n = 15) and with the reticular and papular forms of OLP (n = 15). The control group consisted of six healthy volunteers (one male and five females) without inflammation in the mucous membrane in the oral cavity and without periodontitis. Principal component analysis was used to reveal informative features in the experimental data. The one-versus-one multiclass classifier using support vector machine binary classifiers was used. The two-stage classification approach using several absorption spectra scans for an individual saliva sample provided 100% accuracy of differential classification between OLP subgroups and control group.

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Yury V. Kistenev, Alexey V. Borisov, Maria A. Titarenko, Olga D. Baydik, and Alexander V. Shapovalov "Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics," Journal of Biomedical Optics 23(4), 045001 (13 April 2018). https://doi.org/10.1117/1.JBO.23.4.045001

Received: 31 December 2017; Accepted: 28 March 2018; Published: 13 April 2018

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