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13 February 2019 Comparison of contrast-enhanced digital mammography and contrast-enhanced digital breast tomosynthesis for lesion assessment
Hailiang Huang, David A. Scaduto, Chunling Liu, Jie Yang, Chencan Zhu, Kim Rinaldi, Jason Eisenberg, Jingxuan Liu, Mathias Hoernig, Julia Wicklein, Sebastian Vogt, Thomas Mertelmeier, Paul R. Fisher, Wei Zhao
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Journal of Medical Imaging, Vol. 6, Issue 3, 031407 (February 2019). https://doi.org/10.1117/1.JMI.6.3.031407
Abstract
Contrast-enhanced digital mammography (CEDM) reveals neovasculature of breast lesions in a two-dimensional contrast enhancement map. Contrast-enhanced digital breast tomosynthesis (CEDBT) provides contrast enhancement in three dimensions, which may improve lesion characterization and localization. We aim to compare CEDM and CEDBT for lesion assessment. Women with breast imaging-reporting and data system 4 or 5 suspicious breast lesion(s) were recruited in our study and were imaged with CEDM and CEDBT in succession under one breast compression. Two radiologists assessed CEDM and CEDBT with both images displayed side-by-side and compared (1) contrast enhancement of lesions and (2) lesion margin using a five-point scale ranging from −2 (CEDM much better) to +2 (CEDBT much better). Biopsy identified 19 malignant lesions with contrast enhancement. Our results show that CEDBT provides better lesion margins than CEDM with limited reduction in contrast enhancement. CEDBT delivers less radiation dose compared to CEDM + DBT. Synthetic CEDM can be generated from CEDBT data and provides lesion contrast enhancement comparable to CEDM. CEDBT has potential for clinical applications, such as treatment response monitoring and guidance for biopsy.
© 2019 Society of Photo-Optical Instrumentation Engineers (SPIE) 2329-4302/2019/$25.00 © 2019 SPIE
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Hailiang Huang, David A. Scaduto, Chunling Liu, Jie Yang, Chencan Zhu, Kim Rinaldi, Jason Eisenberg, Jingxuan Liu, Mathias Hoernig, Julia Wicklein, Sebastian Vogt, Thomas Mertelmeier, Paul R. Fisher, and Wei Zhao "Comparison of contrast-enhanced digital mammography and contrast-enhanced digital breast tomosynthesis for lesion assessment," Journal of Medical Imaging 6(3), 031407 (13 February 2019). https://doi.org/10.1117/1.JMI.6.3.031407
Received: 19 October 2018; Accepted: 10 January 2019; Published: 13 February 2019
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Cited by 11 scholarly publications and 3 patents.
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KEYWORDS
Breast
Digital breast tomosynthesis
Digital mammography
X-rays
Mammography
Biopsy
Medicine
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