Near-infrared measurements of brain oxygenation in stroke

François Moreau; Runze Yang; Vivek Nambiar; Andrew M. Demchuk; Jeff F. Dunn

doi:10.1117/1.NPh.3.3.031403

11 February 2016 Near-infrared measurements of brain oxygenation in stroke

François Moreau, Runze Yang, Vivek Nambiar, Andrew M. Demchuk, Jeff F. Dunn

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Neurophotonics, Vol. 3, Issue 3, 031403 (February 2016). https://doi.org/10.1117/1.NPh.3.3.031403

Abstract

We investigated the feasibility of using frequency-domain near-infrared spectroscopy (fdNIRS) to study brain oxygenation in the first few hours of stroke onset. The OxiplexTS® fdNIRS system was used in this study. Using a standard probing protocol based on surface landmarks, we measured brain tHb and S_tO₂ in healthy volunteers, cadavers, and acute stroke patients within 9 h of stroke onset and 3 days later. We obtained measurements from 11 controls, 5 cadavers, and 5 acute stroke patients. S_tO₂ values were significantly lower in cadavers compared to the controls and stroke patients. Each stroke patient had at least one area with reduced S_tO₂ on the stroke side compared to the contralateral side. The evolution of tHb and S_tO₂ at 3 days differed depending on whether a large infarct occurred. This study shows the proof of principle that quantified measurements of brain oxygenation using NIRS could be used in the hectic environment of acute stroke management. It also highlights the current technical limitations and future challenges in the development of this unique bedside monitoring tool for stroke.

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François Moreau, Runze Yang, Vivek Nambiar, Andrew M. Demchuk, and Jeff F. Dunn "Near-infrared measurements of brain oxygenation in stroke," Neurophotonics 3(3), 031403 (11 February 2016). https://doi.org/10.1117/1.NPh.3.3.031403

Published: 11 February 2016

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