Dr. Adrian P. Neculae Profile

Dr. Adrian P. Neculae

at Univ de Vest din Timisoara

SPIE Involvement:

Author

Proceedings Article | 20 March 2013 Paper

Numerical analysis of the diffusive mass transport in brain tissues with applications to optical sensors

Adrian Neculae, Andreas Otte, Dan Curticapean

Proceedings Volume 8576, 857605 (2013) https://doi.org/10.1117/12.2004436

KEYWORDS: Brain, Tissues, Diffusion, Molecules, Optical sensors, Neuroimaging, Optical fibers, Glucose, Optical imaging, Positron emission tomography

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In the brain-cell microenvironment, diffusion plays an important role: apart from delivering glucose and oxygen from the vascular system to brain cells, it also moves informational substances between cells. The brain is an extremely complex structure of interwoven, intercommunicating cells, but recent theoretical and experimental works showed that the classical laws of diffusion, cast in the framework of porous media theory, can deliver an accurate quantitative description of the way molecules are transported through this tissue. The mathematical modeling and the numerical simulations are successfully applied in the investigation of diffusion processes in tissues, replacing the costly laboratory investigations. Nevertheless, modeling must rely on highly accurate information regarding the main parameters (tortuosity, volume fraction) which characterize the tissue, obtained by structural and functional imaging. The usual techniques to measure the diffusion mechanism in brain tissue are the radiotracer method, the real time iontophoretic method and integrative optical imaging using fluorescence microscopy. A promising technique for obtaining the values for characteristic parameters of the transport equation is the direct optical investigation using optical fibers. The analysis of these parameters also reveals how the local geometry of the brain changes with time or under pathological conditions. This paper presents a set of computations concerning the mass transport inside the brain tissue, for different types of cells. By measuring the time evolution of the concentration profile of an injected substance and using suitable fitting procedures, the main parameters characterizing the tissue can be determined. This type of analysis could be an important tool in understanding the functional mechanisms of effective drug delivery in complex structures such as the brain tissue. It also offers possibilities to realize optical imaging methods for in vitro and in vivo measurements using optical fibers. The model also may help in radiotracer biomarker models for the understanding of the mechanism of action of new chemical entities.

Proceedings Article | 5 May 2008 Paper

A simple but accurate multiband solar cells model

Marius Paulescu, Eugenia Tulcan-Paulescu, Adrian Neculae, Paul Gravila

Proceedings Volume 7002, 70020T (2008) https://doi.org/10.1117/12.779434

KEYWORDS: Solar cells, Absorption, Solar energy, Quantum dots, Photons, Computing systems, Quantum wells, Electro optical modeling, Semiconductors, Superlattices

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Proceedings Article | 5 May 2008 Paper

Modeling and numerical simulation of the transport processes inside DSSC using a monodomain approach

Adrian Neculae, Marius Paulescu, Dan Curticapean

Proceedings Volume 7002, 70020Y (2008) https://doi.org/10.1117/12.779264

KEYWORDS: Dye sensitized solar cells, Diffusion, Transparent conductors, Glasses, Numerical simulations, Solar cells, Electrodes, Computer simulations, Interfaces, Titanium dioxide

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Proceedings Article | 28 April 2008 Paper

Temperature measurement using optical fiber with applications to automobiles considering a highly accurate numerical solution for the conductive heat transport in a circular cylinder

Dan Curticapean, Adrian Neculae

Proceedings Volume 7003, 70032K (2008) https://doi.org/10.1117/12.781034

KEYWORDS: Convection, Temperature metrology, Optical fibers, Computer simulations, Finite element methods, Body temperature, Bessel functions, Optical testing, Numerical analysis, Metals

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Proceedings Article | 23 February 2000 Paper

Influence of the precrystallization zone on the dopant field in microgravity

Agneta Balint, Diana Baltean, Monica Mihailovici, Adrian Neculae, Stefan Balint

Proceedings Volume 4068, (2000) https://doi.org/10.1117/12.378692

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Conference Committee Involvement (2)

SPIE Eco-Photonics 2011: Sustainable Design, Manufacturing, and Engineering Workforce Education for a Green Future

28 March 2011 | Strasbourg, France

Education for a Sustainable Engineering Workforce for a Green Future

28 March 2011 | Strasbourg, France

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