Structural and functional dysregulation of the retinal microvasculature have been implicated in the pathogenesis of glaucomatous optic neuropathy. To detect relative blood perfusion heterogeneity in the macular circulation in subjects with glaucoma and healthy controls, we used a commercial optical coherence tomography angiography (OCTA) system with a custom post-acquisition image processing software, involving multi-volume registration and averaging. In 10 subjects diagnosed with glaucoma and 5 control subjects, we observed differences among patient groups in retinal vasculature perfusion heterogeneity, as a potential marker for vascular dysregulation.
Our research investigates retinal pigmentary abnormalities in retinitis pigmentosa (RP) patients using a wide-field high-speed polarization diversity optical coherence tomography (PD-OCT) in a clinical setting. To account for the retinal curvature in the wide field-of-view, adaptive kernel-based spatial averaging is employed for degree-of-polarization-uniformity (DOPU) contrast formation with two complex OCT signals from two orthogonal polarization channels. In 7 patients diagnosed with RP, retinal pigment epithelium (RPE) melanin loss centered at the macula is compared to standard multimodal imaging techniques, including intensity-based OCT, fundus photography, and short-wavelength fundus autofluorescence images.
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