We developed a wearable system for wireless monitoring of oxygenation of deep tissues such as liver and lung during exercise. It is also useful where subcutaneous fat thickness is high. Our system utilizes Continuous Wave Near Infrared Spectroscopy (CW NIRS) with source-detector distances from 10mm to 60mm. This allows us to observe tissues at various depths. To mitigate the interference of the overlaying tissue layers such as skin, fat and muscle, we developed a multi-layer Monte Carlo model for photon diffusion. Flexible structure of our device helps achieve better skin contact and expand its usability to most body parts.
Dynamic Full-Field Optical Coherence Tomography (D-FFOCT) is a high transverse resolution version of OCT that records signal at the output of the interferometer as a movie over a few seconds. Analyzing the temporal variation of the signals reveals intracellular contrast which gives D-FFOCT the capability of identifying dynamic metabolic changes. We use D-FFOCT to identify oxygen induced changes in cellular metabolism at ambient (22%) oxygenation and at hypoxia (1%). Signal strength, calculated as an integral of the raw FFT spectrum, is significantly higher for 1% samples compared to 22% indicating that D-FFOCT is sensitive to changes in cell metabolism.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.