Many studies have shown that iterative reconstruction (IR) algorithm is possible to make the tube current and/or voltage in CT imaging lower without a major loss of image quality. However, there are not many studies on the acquisition conditions for low dose CT images using IR algorithm to achieve the same image quality as routine dose images using FBP algorithm. The aim of this study was to investigate the image quality of low dose CT images obtained with IR algorithm. Images were reconstructed with filtered back projection (FBP) and iDose4 hybrid IR algorithm (Philips Healthcare, Cleveland, OH). CTDIvol for routine protocol and low dose protocol were 5.2 mGy, and 2 mGy, respectively. Images were quantitatively assessed through Hounsfield unit (HU), noise power spectrum (NPS) and contrast to noise ratio (CNR). The results showed that image quality of iDose4 algorithm was improved than that of FBP algorithm. When the same low-dose protocol is used, the IR algorithm provided improved imaging performance compared with the FBP algorithm, and also demonstrated that IR algorithm provides potential for maintaining or improving image quality with much less radiation dose than FBP algorithm with routine dose.
Polychromatic X-ray in computed tomography (CT) can cause metal artifacts and beam hardening artifacts, which are limiting factors in the detection and diagnosis of lesions. Several groups have introduced virtual monochromatic imaging (VMI) techniques using dual-source CT to reduce these artifacts. However, the dual-source system with two exposures can increase the patient dose. The photon-counting detector with one exposure can replace a dual-source system. In this study, we investigated the feasibility of VMI in a photon-counting system. A prototype of the photon-counting CT system, which has 64 line-pixels Cadmium Zinc Telluride (CZT)-based photon-counting detector, was used. The source-to-detector distance and the source-to-center of rotation distance were 1,400 and 1,200 mm, respectively. Energy bins were set at 23 - 32, 33 - 42, 43 - 52, 53 - 62, and 63 - 90 keV. For comparison, the integrating mode was obtained by sum of five energy bins, which is assumed to polychromatic X-ray. Two copper (Cu) rods were inserted into PMMA cylinder phantom. As results, the VMI effectively removed metal artifacts. Noise and Signal-to-noise ratio (SNR) were evaluated and the optimal VMI was measured at 77 keV. Our results indicated that VMI in the prototype of the photon-counting system effectively eliminates the metal artifact and provides better image quality than integrating mode at 23 - 90 keV.
Quantitative imaging analysis has become a focus of medical imaging fields in recent days. In this study, Fourier-based imaging metrics for task-based quantitative assessment of lung nodules were applied in low-dose chest tomosynthesis. Compared to the conventional filtered back-projection (FBP), a compressed-sensing (CS) image reconstruction has been proposed for dose and artifact reduction. We implemented the CS-based low-dose reconstruction scheme to a sparsely sampled projection dataset and compared the lung nodule detectability index (d’) between the FBP and CS methods. We used the non-prewhitening (NPW) model observer to estimate the in-plane slice detectability in tomosynthesis and theoretically calculated d’ using the weighted amounts of local noise, spatial resolution, and task function in Fourier domain. We considered spatially varying noise and spatial resolution properties because the iterative reconstruction showed non-stationary characteristics. For analysis of task function, we adopted a simple binary hypothesis-testing model which discriminates outer and inner region of the encapsulated shape of lung nodule. The results indicated that the local noise power spectrum showed smaller intensities with increasing the number of projections, whereas the local transfer function provided similar appearances between the FBP and CS schemes. The resulted task functions for the same size of lung nodules showed the same pattern with different intensity, whereas the task function for different size of lung nodules presented different shapes due to different object functions. The theoretically calculated d’ values showed that the CS schemes provided higher values than the FBP method by factors of 2.64-3.47 and 2.50-3.10 for two different lung nodules among all projection views. This could demonstrate that the low-dose CS algorithm provide a comparable lung nodule images in comparison to FBP from 37.9% up to 28.8% reduced dose in the same projection views. Moreover, we observed that the CS method implemented with small number of projections provided similar or somewhat higher d’ values compared to the FBP method with large number of projections. In conclusion, the CS scheme may present a potential dose reduction for lung nodule detection in the chest tomosynthesis by showing higher d’ in comparison to the conventional FBP method.
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