KEYWORDS: Lawrencium, Image resolution, Super resolution, Convolutional neural networks, Cancer, Scanners, Data modeling, Image segmentation, Convolution, Signal to noise ratio
We study a problem scenario of super-resolution (SR) algorithms in the context of whole slide imaging (WSI), a popular imaging modality in digital pathology. Instead of just one pair of high- and low-resolution images, which is typically the setup in which SR algorithms are designed, we are given multiple intermediate resolutions of the same image as well. The question remains how to best utilize such data to make the transformation learning problem inherent to SR more tractable and address the unique challenges that arises in this biomedical application. We propose a recurrent convolutional neural network model, to generate SR images from such multi-resolution WSI datasets. Specifically, we show that having such intermediate resolutions is highly effective in making the learning problem easily trainable and address large resolution difference in the low and high-resolution images common in WSI, even without the availability of a large size training data. Experimental results show state-of-the-art performance on three WSI histopathology cancer datasets, across a number of metrics.
Matching geometric objects is a fundamental problem in computational geometry with applications in many other areas, such as computer vision, biology,and archaelogy. In this paper, we study an important partial matching problem motivated from applications in several such areas. The input is in the form of sets of under-sampled slices of one (or more) unknown 3D objects, possibly generated by slicing planes of arbitrary orientations, the question we are interested in is whether it is 'possible' that two under-sampled sets have been taken from the same object. Alternatively, can we determine with 'certainty' that the given input samples cannot be from the same object. We present efficient algorithms for addressing these questions. Our algorithm is based on interesting geometric techniques and enables answering these queries either as plausible or a certain negative.
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