We demonstrate the feasibility of multiphoton fluorescence imaging with high spatial resolution using commercially available single-core 50/125 multimode graded-index fiber. Light propagating forward inside the endoscopic fiber undergoes a non-reciprocal propagation exhibiting a robust nonlinear spatial self-cleaning process. Whereas fluorescence from nonlinear interactions with biological samples linearly propagates backward along the same fiber. The scanner head, located at the distal end of the endoscope and suited for multimode fibers, is based on a ceramic tube where the fiber end follows a spiral course to explore the sample. No knowledge of the fiber transfer matrix is required.
Antibacterial items are one of the major queries from the medical community in the fight against medical infections. Indeed, bacteria are resistant and their multiplication and biofilm formation on devises are one of the major causes of infections. Finding antibacterial surfaces, which are biocompatible, cost-effective, not toxic, and spreadable over large and irregular surfaces, is not easy. However, we created an antibacterial cloak by laser printing of Graphene Oxide (GO) hydrogels by mimicking the Cancer Pagurus carapace. This surface provides up to 90% reduction of bacteria cells through a bacteriostatic and bactericidal effect. Indeed, Laser treating allows GO sheets gel to cut and wrap microorganisms. Our findings are confirmed by a theoretical active matter model. This new technology based on antibiotic-free biomimetic Graphene Oxide gels opens untrodden roads to the fight against infections in biomedical applications and chirurgical equipment.
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