Dr. Matthew P. Fronheiser Profile

Dr. Matthew P. Fronheiser

at Seno Medical Instruments

SPIE Involvement:

Author

Publications (10)

SPIE Journal Paper | 1 March 2010 Open Access

Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature

Matthew Fronheiser, Sergey Ermilov, Hans-Peter Brecht, André Conjusteau, Richard Su, Ketan Mehta, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021305, (March 2010) https://doi.org/10.1117/12.10.1117/1.3370336

KEYWORDS: Arteries, Veins, Blood vessels, Visualization, Imaging systems, Video, Ultrasonography, Real time imaging, Skin, Blood circulation

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SPIE Journal Paper | 1 March 2010 Open Access

Optoacoustic imaging of the prostate: development toward image-guided biopsy

Mohammad Yaseen, Sergey Ermilov, Hans-Peter Brecht, Richard Su, André Conjusteau, Matthew Fronheiser, Brent Bell, Massoud Motamedi, Alexander Oraevsky

JBO, Vol. 15, Issue 02, 021310, (March 2010) https://doi.org/10.1117/12.10.1117/1.3333548

KEYWORDS: Prostate, Tissues, Acoustics, Tissue optics, Signal detection, Biopsy, In vivo imaging, Imaging systems, Tumors, Signal processing

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Proceedings Article | 26 February 2010 Paper

In vivo 3D visualization of peripheral circulatory system using linear optoacoustic array

Sergey Ermilov, Hans-Peter Brecht, Matthew Fronheiser, Vyacheslav Nadvoretsky, Richard Su, Andre Conjusteau, Alexander Oraevsky

Proceedings Volume 7564, 756422 (2010) https://doi.org/10.1117/12.847933

KEYWORDS: Blood vessels, Arteries, Computer simulations, Veins, Absorption, Skin, 3D image processing, Blood, In vivo imaging, Laser beam diagnostics

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Proceedings Article | 24 February 2010 Paper

Real-time optoacoustic imaging of breast cancer using an interleaved two laser imaging system coregistered with ultrasound

Sergey Ermilov, Matthew Fronheiser, Vyacheslav Nadvoretsky, Hans-Peter Brecht, Richard Su, André Conjusteau, Ketan Mehta, Pamela Otto, Alexander Oraevsky

Proceedings Volume 7564, 75641W (2010) https://doi.org/10.1117/12.847946

KEYWORDS: Tumors, Breast, Breast cancer, Ultrasonics, Imaging systems, Ultrasonography, Blood vessels, Mammography, Deconvolution, Visualization

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SPIE Journal Paper | 1 November 2009 Open Access

Whole-body three-dimensional optoacoustic tomography system for small animals

Hans-Peter Brecht, Richard Su, Matthew Fronheiser, Sergey Ermilov, André Conjusteau, Alexander Oraevsky

JBO, Vol. 14, Issue 06, 064007, (November 2009) https://doi.org/10.1117/12.10.1117/1.3259361

KEYWORDS: Tomography, Transducers, 3D image processing, Imaging systems, Opacity, Visualization, Video, Veins, Tissue optics, Kidney

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Proceedings Article | 13 March 2009 Paper

The ultrasound brain helmet: early human feasibility study of multiple simultaneous 3D scans of cerebral vasculature

Brooks Lindsey, Nikolas Ivancevich, John Whitman, Edward Light, Matthew Fronheiser, Heather Nicoletto, Daniel Laskowitz, Stephen Smith

Proceedings Volume 7265, 726503 (2009) https://doi.org/10.1117/12.810644

KEYWORDS: 3D scanning, Transducers, Ultrasonography, Brain, 3D image processing, Doppler effect, Neuroimaging, Arteries, Skull, Acoustics

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Proceedings Article | 25 February 2009 Paper

Characterization of optoacoustic transducers through the analysis of angular-dependent frequency response

André Conjusteau, Sergey Ermilov, Richard Su, Hans-Peter Brecht, Matthew Fronheiser, Alexander Oraevsky

Proceedings Volume 7177, 71770U (2009) https://doi.org/10.1117/12.812339

KEYWORDS: Transducers, Acoustics, Sensors, Calibration, Wavefronts, Ultrasonography, Signal attenuation, Pulsed laser operation, Image restoration, Signal to noise ratio

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Proceedings Article | 25 February 2009 Paper

Optoacoustic 3D whole-body tomography: experiments in nude mice

Hans-Peter Brecht, Richard Su, Matt Fronheiser, Sergey Ermilov, André Conjusteau, Anton Liopo, Massoud Motamedi, Alexander Oraevsky

Proceedings Volume 7177, 71770E (2009) https://doi.org/10.1117/12.812319

KEYWORDS: Blood vessels, Linear filtering, Wavelets, Tomography, Electronic filtering, Transducers, Imaging systems, Tissue optics, 3D image processing, Alexandrite lasers

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Proceedings Article | 25 February 2009 Paper

Development of laser optoacoustic and ultrasonic imaging system for breast cancer utilizing handheld array probes

Sergey Ermilov, Matthew Fronheiser, Hans-Peter Brecht, Richard Su, André Conjusteau, Ketan Mehta, Pamela Otto, Alexander Oraevsky

Proceedings Volume 7177, 717703 (2009) https://doi.org/10.1117/12.812192

KEYWORDS: Breast, Transducers, Tumors, Acoustics, Ultrasonics, Imaging systems, 3D modeling, Signal processing, Visualization, Tissue optics

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We describe two laser optoacoustic imaging systems for breast cancer detection based on arrays of acoustic detectors operated manually in a way similar to standard ultrasonic breast imaging. The systems have the advantages of standard light illumination (regardless of the interrogated part of the breast), the ability to visualize any part of the breast, and convenience in operation. The first system could work in both ultrasonic and optoacoustic mode, and was developed based on a linear ultrasonic breast imaging probe with two parallel rectangular optical bundles. We used it in a pilot clinical study to provide for the first time demonstration that the boundaries of the tumors visualized on the optoacoustic and ultrasonic images matched. Such correlation of coregistered images proves that the objects on both images represented indeed the same tumor. In the optoacoustic mode we were also able to visualize blood vessels located in the neighborhood of the tumor. The second system was proposed as a circular array of acoustic transducers with an axisymmetric laser beam in the center. It was capable of 3D optoacoustic imaging with minimized optoacoustic artifacts caused by the distribution of the absorbed optical energy within the breast tissue. The distribution of optical energy absorbed in the bulk tissue of the breast was removed from the image by implementing the principal component analysis on the measured signals. The computer models for optoacoustic imaging using these two handheld probes were developed. The models included three steps: (1) Monte Carlo simulations of the light distribution within the breast tissue, (2) generation of optoacoustic signals by convolving N-shaped pressure signals from spherical voxels with the shape of individual transducers, and (3) back-projecting processed optoacoustic signals onto spherical surfaces for image reconstruction. Using the developed models we demonstrated the importance of the included spatial impulse response of the optoacoustic imaging system.

Proceedings Article | 28 February 2008 Paper

Optoacoustic system for 3D functional and molecular imaging in nude mice

Matthew Fronheiser, Alan Stein, Don Herzog, Scott Thompson, Anton Liopo, Mohammad Eghtedari, Massoud Motamedi, Sergey Ermilov, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Ketan Mehta, Alexander Oraevsky

Proceedings Volume 6856, 68560R (2008) https://doi.org/10.1117/12.770461

KEYWORDS: Imaging systems, Tissues, Tumors, Sensors, Gold, Molecular imaging, Image resolution, 3D image processing, Tissue optics, Nanorods

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A three-dimensional laser optoacoustic imaging system was developed, which combines the advantages of optical spectroscopy and high resolution ultrasonic detection, to produce high contrast maps of optical absorbance in tissues. This system was tested in a nude mouse model of breast cancer and produced tissue images of tumors and vasculature. The imaging can utilize either optical properties of hemoglobin and oxyhemoglobin, which are the main endogenous tissue chromophores in the red and near-infrared spectral ranges, or exogenous contrast agent based on gold nanorods. Visualization of tissue molecules targeted by the contrast agent provides molecular information. Visulization of blood at multiple colors of light provides functional information on blood concentration and oxygen saturation. Optoacoustic imaging, using two or more laser illumination wavelengths, permits an assessment of the angiogenesis-related microvasculature, and thereby, an evaluation of the tumor stage and its metastatic potential. The optoacoustic imaging system was also used to generate molecular images of the malignancy-related receptors induced by the xenografts of BT474 mammary adenocarcinoma cells in nude mice. The development of the latter images was facilitated by the use of an optoacoustic contrast agent that utilizes gold nanorods conjugated to monoclonal antibody raised against HER2/neu antigens. These nanorods possess a very strong optical absorption peak that can be tuned in the near-infrared by changing their aspect ratio. The effective conversion of the optical energy into heat by the gold nanorods, followed by the thermal expansion of the surrounding water, makes these nanoparticles an effective optoacoustic contrast agent. Optical scattering methods and x-ray tomography may also benefit from the application of this contrast agent. Administration of the gold nanorod bioconjugates to mice resulted in an enhanced contrast of breast tumors relative the background of normal tissues in the nude mouse model. The combination of this novel contrast agent and optoacoustic imaging has the potential to become a useful imaging modality, for preclinical research in murine models of cancer and other human diseases.

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