Our efforts to disentangle the link between molecular recognition and biochemical function are centered on the study of binding and dynamics of protein-RNA complexes at electrified interfaces. We are interested in the effects of electrostatics and local dynamics on the formation and stability of RNA-protein complexes. The use of complementary multimodal observations enables us to distinguish between distinct stages in the binding event between an RNA-binding protein and its target -- both of which are affected by interfacial electric fields. To follow dynamic events over multiple time scales, we combine mid-infrared surface plasmonics, time-resolved ultrafast fluorescence, and in situ electrochemical experiments at the surface of a degenerately doped wide-gap metal oxide.
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