A design incorporating surface plasmon resonance (SPR) biosensing and surface acoustic wave (SAW) active
microfluidic mixing, integrated on a single LiNbO3 piezoelectric substrate, is presented. Validation experiments show
that SAW-mixing (microstreaming) results in accelerated binding kinetics (time-to-saturation) for a standard assay with
appropriate SAW excitation parameters. Since both SPR sensors and SAW transducers can be fabricated simultaneously
using low-cost microfabrication methods, the proposed design should contribute to improved lab-on-chip devices for
detecting and identifying biomolecules of interest with greater accuracy and speed across multiple applications.
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