Ms. Xueyan Liu Profile

Xueyan Liu

at Nanchang Univ

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Publications (4)

Proceedings Article | 5 March 2021 Poster + Paper

Virtual Bessel-beam photoacoustic microscopy with extended depth of field using k-Wave

Xueyan Liu, Jianshuang Wei, Lingfang Song, Xianlin Song

Proceedings Volume 11642, 116424D (2021) https://doi.org/10.1117/12.2582900

KEYWORDS: Photoacoustic microscopy, Photoacoustic spectroscopy, Photoacoustic imaging, Image resolution, Bessel beams, Virtual reality, Tissue optics, Imaging systems, Gaussian beams, Tumors

Read Abstract +

Photoacoustic imaging technology is a new imaging technology has emerged in recent years, which combines the advantages of optical imaging and acoustic imaging, optical imaging and acoustic imaging have their own advantages, optical imaging has rich contrast , acoustic imaging has high resolution and high penetration. Photoacoustic imaging has been widely used in biomedical fields, such as brain imaging, tumor detection. As an important branch of photoacoustic imaging technology, optical-resolution photoacoustic microscopy can be applied from cells to tissues. However, the traditional optical-resolution photoacoustic microscopy usually uses a tight focused gaussian beam, the depth-of-field is small, and it is difficult to achieve rapid large volumetric imaging. In order to overcome this issue, researchers have proposed many solutions, one of which is to replace gaussian beams with non-diffracted beams. Bessel beam, as a nondiffracted beam, has a large depth of field. We applied it to optical -resolution photoacoustic microscopy. In reality, the cost of building such a Bessel-beam photoacoustic microscopy is relatively high and the system is complicated. Therefore, a virtual simulation technology is urgently needed for simulation research. Here, we proposed a virtual simulation platform of Bessel-beam photoacoustic microscopy based on k-Wave. The platform generates Bessel beam in the focus area of the objective lens by the circular slit, and the Bessel beam irradiates on the sample to generate the initial photoacoustic pressure field in a wide depth range. The k-Wave is used to simulate the propagation of photoacoustic fields, record photoacoustic signals and image reconstruction. The three-dimensional imaging of vascular network further verifies the large depth of field of Bessel-beam photoacoustic microscopy simulation platform. The establishment of the simulation platform is of great significance to the theoretical research of Bessel-beam photoacoustic microscopy and its application in biomedicine.

Proceedings Article | 5 March 2021 Presentation + Paper

Vortex-beam photoacoustic microscopy for enhancing the depth of field

Cong Liu, Jiahao Zeng, Xianlin Song, Ao Teng, Jianshuang Wei, Lingfang Song, Xueyan Liu

Proceedings Volume 11642, 116423R (2021) https://doi.org/10.1117/12.2589253

KEYWORDS: Photoacoustic spectroscopy, Microrings, Tissues, Signal detection, Resonators, Ultrasonics, Finite element methods, Photoacoustic imaging, Brain, Pulsed laser operation

Read Abstract +

Photoacoustic imaging technology is a new functional imaging method in biomedical application field. It is based on photoacoustic effect. It combines the advantages of high resolution and rich contrast of optical imaging with the advantages of high penetration depth of acoustic imaging. It can be used for noninvasive detection of structural, functional and molecular abnormalities in biological tissues, Multi scale information of micro and macro world is detected. Photoacoustic microscope is a micro imaging device based on photoacoustic effect. It can measure the amplitude and phase of photoacoustic signals generated at different positions on the solid surface, so as to determine the optical properties, thermal properties, elasticity or geometric structure of samples. However, the traditional optical resolution photoacoustic microscopy imaging system usually uses strong focused Gaussian beam, which has long imaging time and weak penetrating ability, so it is difficult to achieve fast imaging of solid inner surface. The vortex beam has the characteristics of spiral wavefront structure, circular distribution of light intensity, definite orbital angular momentum and phase singularity. Based on the above characteristics, vortex light has high directivity, wide frequency band and wide bandwidth, which can be used for deep and efficient penetrating imaging of inner surface. In this paper, Matlab is used to generate the ideal and transmitted vortex light phase diagram and spot, and then k-wave simulation software is used to build the virtual simulation platform of vortex photoacoustic microscopy imaging system. In the MATLAB simulation, the vortex light beam irradiates on the vascular cells to image the vascular tissue. The results show that vorticity light has better penetrating ability and faster imaging speed than Gaussian light. This study is helpful to detect the deep structure and properties of vascular cells by using vortex light, and put forward a new idea for the deep fast imaging of solid surface.

Proceedings Article | 28 February 2021 Paper

Airy-beam photoacoustic microscope imaging platform based on k-space pseudo-spectral method

Xianlin Song, Ganyu Chen, Xueyan Liu, Jianshuang Wei, Lingfang Song

Proceedings Volume 11781, 117810O (2021) https://doi.org/10.1117/12.2591386

Read Abstract +

As an emerging nondestructive imaging technology recently, Photoacoustic imaging (PAI), which is based on Photoacoustic effect, combines the advantages: the high resolution and contrast of optical imaging and the high penetration depth of acoustic imaging. Thereinto, as a branch of Photoacoustic imaging, Photoacoustic microimaging inherited the advantages of Photoacoustic imaging. The unique focusing mode of Photoacoustic microimaging can meet the requirements of higher resolution in biological imaging, thus, it gained extensive applications in medical science field. However, on account of using high numerical aperture objective lens strongly focus on Gaussian beam, traditional Photoacoustic microimaging system has shallow depth of imaging field, and its transverse resolution and signal-to-noise ratio deteriorate rapidly outside the focal point, limiting the velocity of large volume imaging. Owing to solve these problems, in this paper, we build a simulation platform for Airy beam photoacoustic microscopy based on K-Wave simulation toolbox. This platform uses Airy beam to inspire initial Photoacoustic signal in large volume and K-Wave simulation toolbox to simulate the propagation, recording and reconstruction process of Photoacoustic signal. As Nondiffraction beam, Airy beam features the capacity of large depth of field, thus, its application could reach the requirement of large depth of field imaging of Photoacoustic microscopy system. Measuring the performances of the constructed Photoacoustic microscopy system, we constructed three-dimensional imaging of the blood vessel. By simulating A-Scan, B-Scan and C-Scan, we measured the performances of this system, such as axial resolution, transverse resolution and depth of field. Meanwhile, the three-dimensional imaging of the vertically tilted fiber also verified the three-dimensional imaging capability of the Airy beam photoacoustic microscopy simulation platform. The establishment of the simulation platform has a significance for the theoretical research of photoacoustic microscopy and its application in biomedicine.

Proceedings Article | 8 November 2020 Poster + Paper

Bessel-beam photoacoustic microscopy based on k-space pseudospectral method: simulation study

Xianlin Song, Xueyan Liu, Xiaokai Zhou, Aojie Zhao, Jianshuang Wei, Lingfang Song

Proceedings Volume 11525, 115252M (2020) https://doi.org/10.1117/12.2584874

KEYWORDS: Photoacoustic microscopy, Tissue optics, Photoacoustic spectroscopy, Image resolution, Biomedical optics, Bessel beams, Virtual reality, Photoacoustic imaging, Imaging systems, Gaussian beams

Read Abstract +

Photoacoustic imaging technology is a new imaging technology has emerged in recent years, which combines the advantages of optical imaging and acoustic imaging, optical imaging and acoustic imaging have their own advantages, optical imaging has rich contrast , acoustic imaging has high resolution and high penetration. Photoacoustic imaging has been widely used in biomedical fields, such as brain imaging, tumor detection. As an important branch of photoacoustic imaging technology, optical-resolution photoacoustic microscopy can be applied from cells to tissues. However, the traditional optical-resolution photoacoustic microscopy usually uses a tight focused gaussian beam, the depth-of-field is small, and it is difficult to achieve rapid large volumetric imaging. In order to overcome this issue, researchers have proposed many solutions, one of which is to replace gaussian beams with non-diffracted beams. Bessel beam, as a nondiffracted beam, has a large depth of field. We applied it to optical -resolution photoacoustic microscopy. In reality, the cost of building such a Bessel-beam photoacoustic microscopy is relatively high and the system is complicated. Therefore, a virtual simulation technology is urgently needed for simulation research. Here, we proposed a virtual simulation platform of Bessel-beam photoacoustic microscopy based on k-Wave toolbox. The platform generates Bessel beam in the focus area of the objective lens by the circular slit, and the Bessel beam irradiates on the sample to generate the initial photoacoustic pressure field in a wide depth range. The K-Wave toolbox is used to simulate the propagation of photoacoustic fields, record photoacoustic signals and image reconstruction. The system can image a vascular network. The three-dimensional imaging of vascular network further verifies the large depth of field of Bessel-beam photoacoustic microscopy simulation platform. The establishment of the simulation platform is of great significance to the theoretical research of Bessel-beam photoacoustic microscopy and its application in biomedicine.

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