Dr. Yuri I. Gurfinkel Profile

Dr. Yuri I. Gurfinkel

at Central Clinical Hospital

SPIE Involvement:

Author

Proceedings Article | 18 June 2004 Paper

Noninvasive estimation of tissue edema in healthy volunteers and in patients suffering from heart failure

Yuri Gurfinkel, Valery Mikhailov, Marina Kudutkina

Proceedings Volume 5325, (2004) https://doi.org/10.1117/12.530442

KEYWORDS: Capillaries, Tissues, Heart, Blood, Failure analysis, Video, Blood circulation, Magnesium, Molecules, Biomedical optics

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Capillaries play a critical role in cardiovascular function as the point of exchange of nutrients and waste products between tissues and circulation. A common problem for healthy volunteers examined during isolation, and for the patients suffering from heart failure is a quantitative estimation tissue oedema. Until now, objective assessment body fluids retention in tissues did not exist. Optical imaging of living capillaries is a challenging and medically important scientific problem. Goal of the investigation was to study dynamic of microcriculation parameters including tissue oedema in healthy volunteers during extended isolation and relative hypokinesia as a model of mission to the International Space Station. The other aim was to study dynamic of microcirculation parameters including tissue oedema in patients suffering from heart failure under treatment. Healthy volunteers and patients. We studied four healthy male subjects at the age of 41, 37, 40, and 48 before the experiment (June 1999), and during the 240-d isolation period starting from July3, 1999. Unique hermetic chambers with artidicial environmental parameters allowed performing this study with maximum similarity to real conditions in the International Space Station (ISS). With the regularity of 3 times a week at the same time, each subject recorded three video episodes with the total length of one-minute using the optical computerized capillaroscope for noninvasive measurement of the capillary diameters sizes, capillary blood velocity as well as the size of the perivascular zone. All this parameters of microcirculation determined during three weeks in 15 patients (10 male, 5 female, aged 62,2±8,8) suffering from heart failure under Furosemid 40 mg 2 times a week, as diuretic. Results. About 1500 episodes recorded on laser disks and analyzed during this experiment. Every subject had wave-like variations of capillary blood velocity within the minute, week, and month ranges. It was found that the perivascular zone sizes rising during isolation correlate with body mass of subjects and probably depend on retention of body fluids in tissues. Computerized capillaroscopy provides a new opportunity for non-invasive quantitative estimation tissue oedema and suggests for exact management patients suffering from heart failure under diuretic treatment.

Proceedings Article | 16 July 2002 Paper

Interrelation between metabolic processes in blood and its sedimentation dynamics revealed by the method of ESR-graphy

Yulia Boularguina, Ekaterina Bouravleva, Youri Gurfinkel, Vladimir Voeikov

Proceedings Volume 4707, (2002) https://doi.org/10.1117/12.475587

KEYWORDS: Blood, Oxygen, Plasma, Hydrogen, In vitro testing, Tissues, Capillaries, Interfaces, Chemiluminescence, Lead

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Proceedings Article | 23 May 2002 Paper

New potentialities for noninvasive optical investigation of microcirculation in extended space missions

Youri Gurfinkel, Valery Mikhailov

Proceedings Volume 4624, (2002) https://doi.org/10.1117/12.468314

KEYWORDS: Capillaries, Blood circulation, Space operations, Data modeling, Biomedical optics, Tissues, Blood, Microfluidics, Organisms, Video

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Proceedings Article | 24 October 2001 Paper

Diagnostic applications of an optoelectronic device for high temporal resolution of erythrocyte sedimentation (ESR-graphy)

Vladimir Voeikov, Ekaterina Buravleva, Yulia Bulargina, Youri Gurfinkel

Proceedings Volume 4434, (2001) https://doi.org/10.1117/12.446681

KEYWORDS: Blood, Hydrogen, Plasma, Diagnostics, Lead, Oxygen, In vitro testing, Temporal resolution, Pathology, Pulmonary disorders

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Proceedings Article | 13 June 2001 Paper

Computerized capillaroscopy as a visualization channel for lipid quantification in circulating blood

Youri Gurfinkel, Angela Ishunina, Konstantin Ovsyannickov

Proceedings Volume 4263, (2001) https://doi.org/10.1117/12.429347

KEYWORDS: Blood, Capillaries, Heart, Lithium, Blood circulation, Stomach, Visualization, Molecules, Particles, Skin

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Proceedings Article | 4 May 2001 Paper

Computer capillaroscopy as a channel of local visualization, noninvasive diagnostics, and screening of substances in circulating blood

Youri Gurfinkel

Proceedings Volume 4241, (2001) https://doi.org/10.1117/12.431560

KEYWORDS: Capillaries, Blood circulation, Blood, Tissues, Heart, Video processing, Visualization, Skin, Image enhancement, Signal processing

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Proceedings Article | 22 November 2000 Paper

Quantitative estimation of antioxidant therapy efficiency in diabetes mellitus patients

Youri Gurfinkel, Angela Ishunina, Konstantin Ovsyannickov, Igor Strokov

Proceedings Volume 4163, (2000) https://doi.org/10.1117/12.407645

KEYWORDS: Capillaries, Blood, Blood circulation, Tissues, Skin, Glucose, Magnesium, Oxygen, Doppler effect, Molecules

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Proceedings Article | 22 November 2000 Paper

Effect of geomagnetic storms upon blood sedimentation dynamics in ischemic heart disease patients

Youri Gurfinkel, Vladimir Voeikov, Sergey Kondakov, P. Demidion, Andey Dmitriev, S. Ozerskii

Proceedings Volume 4163, (2000) https://doi.org/10.1117/12.407652

KEYWORDS: Blood, Heart, Polymers, Temporal resolution, Capillaries, Plasma, Solar processes, Magnetism, Oxygen, Statistical analysis

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Proceedings Article | 31 May 2000 Paper

Computerized capillaroscopy as a method of Tanakan therapy efficiency assessment in diabetes patients

Youri Gurfinkel, Angela Ishunina

Proceedings Volume 3923, (2000) https://doi.org/10.1117/12.387138

KEYWORDS: Capillaries, Blood circulation, Blood, Skin, Velocity measurements, Visualization, Magnesium, Laboratory techniques, Kidney, Doppler effect

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Proceedings Article | 19 June 1998 Paper

Dynamics of erythrocyte sedimentation rate as a new diagnostic tool

Sergey Kondakov, Vladimir Voeikov, Youri Gurfinkel, Andey Dmitriev

Proceedings Volume 3252, (1998) https://doi.org/10.1117/12.311898

KEYWORDS: Blood, Diagnostics, Pathology, Standards development, Tissues, Medicine, Laser therapeutics, Therapeutics, Patents, Particles

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Proceedings Article | 29 April 1998 Paper

Computer capillaroscopy as a new cardiological diagnostics method

Youri Gurfinkel, Oleg Korol, George Kufal

Proceedings Volume 3260, (1998) https://doi.org/10.1117/12.307096

KEYWORDS: Capillaries, Blood circulation, Blood, Tissues, Heart, Diagnostics, Arteries, Molecules, Televisions, Skin

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Proceedings Article | 16 June 1997 Paper

Monitoring of rapid blood pH variations by CO detection in breath with tunable diode laser

Andrian Kouznetsov, Eugene Stepanov, Pavel Zyrianov, Yurii Shulagin, Alexander Diachenko, Youri Gurfinkel

Proceedings Volume 2976, (1997) https://doi.org/10.1117/12.275517

KEYWORDS: Carbon monoxide, Blood, Absorption, Gas lasers, Tunable diode lasers, Carbon dioxide, Chemical analysis, Organisms, Lung, Signal detection

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Showing 5 of 12 publications

Conference Committee Involvement (11)

Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics

6 February 2013 | San Francisco, California, United States

Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics

25 January 2012 | San Francisco, California, United States

Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics

26 January 2011 | San Francisco, California, United States

Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics

26 January 2010 | San Francisco, California, United States

Optical Diagnostics and Sensing IX

27 January 2009 | San Jose, California, United States

Showing 5 of 11 Conference Committees

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