One interesting feature of optical frequency comb (OFC) is a function of frequency conversion between region and electric regions. While such feature has been used for generation of correct electric signal in microwave or millimeter region, it can be further used for fiber biosensing; namely, biosensing OFC. In this paper, we demonstrated detection of SARS-CoV-2 antigen based on a combination of dual fiber combs, an intracavity multi-mode-interference fiber sensor, and sensor surface modification of SARS-CoV-2 antibody.
Recently, we have proposed a refractive-index(RI)-sensing optical comb by placing a multi-mode interference (MMI) fiber sensor inside a fiber comb cavity. In this method, change of RI is read out as a repetition frequency frep via photonic RF conversion, and is precisely measured based on a RF frequency standard. If a surface of the intracavity MMI sensor is chemically modified for biosensing, it will be further used for biosensing.
In this paper, we chemically modified the surface of the intracavity MMI fiber sensor with biotin and then read the chemical reaction with avidin as a change in frep.
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