Special Section on Optical Methods of Imaging in the Skin

Use of Raman spectroscopy in the analysis of nickel allergy

[+] Author Affiliations
Javier Alda

University Complutense of Madrid, Applied Optics Complutense Group, Madrid, Spain

Claudio Castillo-Martinez, Rodrigo Valdes-Rodriguez, Diana Hernández-Blanco, Benjamin Moncada

Universidad Autónoma de San Luis Potosí, Hospital Central ‘Dr Ignacio Morones Prieto, Dermatology Department, SLP, México

Francisco J. González

Universidad Autónoma de San Luis Potosí, Coordinación para la Innovación y la Aplicación de la Ciencia y la Tecnología, San Luis Potosí, Mexico

J. Biomed. Opt. 18(6), 061206 (Nov 02, 2012). doi:10.1117/1.JBO.18.6.061206
History: Received July 4, 2012; Revised October 10, 2012; Accepted October 12, 2012
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Abstract.  Raman spectra of the skin of subjects with nickel allergy are analyzed and compared to the spectra of healthy subjects to detect possible biochemical differences in the structure of the skin that could help diagnose metal allergies in a noninvasive manner. Results show differences between the two groups of Raman spectra. These spectral differences can be classified using principal component analysis. Based on these findings, a novel computational technique to make a fast evaluation and classification of the Raman spectra of the skin is presented and proposed as a noninvasive technique for the detection of nickel allergy.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Javier Alda ; Claudio Castillo-Martinez ; Rodrigo Valdes-Rodriguez ; Diana Hernández-Blanco ; Benjamin Moncada, et al.
"Use of Raman spectroscopy in the analysis of nickel allergy", J. Biomed. Opt. 18(6), 061206 (Nov 02, 2012). ; http://dx.doi.org/10.1117/1.JBO.18.6.061206


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